| Gene Symbol |
VIPR1
|
| Entrez Gene |
7433
|
| Alt Symbol |
HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vasoactive intestinal peptide receptor 1
|
| Other Description |
PACAP type II receptor|VIP and PACAP receptor 1|VIP receptor, type I|pituitary adenylate cyclase activating polypeptide receptor, type II|vasoactive intestinal polypeptide receptor 1
|
| Swissprots |
F5H1F5 P32241 Q6P2M6 A5JUT9 G3V0I1 B4DEB5 B3KPV1 B4DGI4 Q15871
|
| Accessions |
AAB60362 BAC05895 CAS01788 EAW64649 EAW64650 EAW64651 EAW64652 P32241 AK056819 BAG51813 AK123943 AK126759 AK293548 BAG57026 AK294609 BAG57795 AK298115 BAG60398 AK314334 BAG36980 BC064424 AAH64424 BU681817 DA200439 EF577396 ABQ52416 L13288 AAA36805 L20295 AAA36802 X75299 CAA53046 XM_005265437 XP_005265494 XM_005265438 XP_005265495 XM_005265439 XP_005265496 XM_011534079 XP_011532381 XM_011534080 XP_011532382 XR_940499 XR_940500 NM_001251882 NP_001238811 NM_001251883 NP_001238812 NM_001251884 NP_001238813 NM_001251885 NP_001238814 NM_004624 NP_004615
|
| Function |
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. {ECO:0000269|PubMed:8926282}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T- cell lines Peer, MOLT-4, HSB and YT. {ECO:0000269|PubMed:8926282}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|