Gene Symbol | EPT1 |
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Entrez Gene | 85465 |
Alt Symbol | SELI, SEPI |
Species | Human |
Gene Type | protein-coding |
Description | ethanolaminephosphotransferase 1 |
Other Description | ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)|hEPT1|selenoprotein I |
Swissprots | Q63ZE3 Q9C0D9 |
Accessions | AAY14646 EAX00690 EAX00691 EAX00692 EAX00693 Q9C0D9 AB051511 BAB21815 AB621826 BAK64161 AK023242 AK091340 AK092710 AK095620 BC015430 BC021229 AAH21229 BE963795 BF669898 BK001426 DAA01514 DA619246 DA905145 EH350337 NM_033505 NP_277040 |
Function | Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe. {ECO:0000269|PubMed:17132865}. |
Top Pathways | Ether lipid metabolism, Glycerophospholipid metabolism |
Selenoprotein I CRISPR/Cas9 KO Plasmid (h) - sc-408993 from Santa Cruz Biotechnology
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Selenoprotein I HDR Plasmid (h) - sc-408993-HDR from Santa Cruz Biotechnology
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Selenoprotein I Double Nickase Plasmid (h) - sc-408993-NIC from Santa Cruz Biotechnology
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Selenoprotein I Double Nickase Plasmid (h2) - sc-408993-NIC-2 from Santa Cruz Biotechnology
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Selenoprotein I CRISPR Activation Plasmid (h) - sc-408993-ACT from Santa Cruz Biotechnology
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Selenoprotein I CRISPR Activation Plasmid (h2) - sc-408993-ACT-2 from Santa Cruz Biotechnology
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Selenoprotein I Lentiviral Activation Particles (h) - sc-408993-LAC from Santa Cruz Biotechnology
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Selenoprotein I Lentiviral Activation Particles (h2) - sc-408993-LAC-2 from Santa Cruz Biotechnology
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Selenoprotein I siRNA (h) - sc-61516 from Santa Cruz Biotechnology
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Selenoprotein I shRNA Plasmid (h) - sc-61516-SH from Santa Cruz Biotechnology
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Selenoprotein I shRNA (h) Lentiviral Particles - sc-61516-V from Santa Cruz Biotechnology
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SELI RNAi - H00085465-R01 from Novus Biologicals
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MISSION® esiRNA - EHU014511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7940 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7940 from Sigma-Aldrich
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EPT1 siRNA (Human) - CRJ3831 from Cohesion Biosciences
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EPT1 - MBS8223259 from MyBioSource
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shRNA set against Human EPT1 (NM_033505.2) - SHH286733 from Creative biogene
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shRNA set against Human SELI(NM_033505.2) - SHR213006 from Creative biogene
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EPT1 shRNA Plasmid (Human) - CHJ3831 from Cohesion Biosciences
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EPT1 miRNA 3'UTR clone - MiUTR1H-09240 from Creative biogene
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