EXO1

Gene Symbol EXO1
Entrez Gene 9156
Alt Symbol HEX1, hExoI
Species Human
Gene Type protein-coding
Description exonuclease 1
Other Description hExo1|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Swissprots Q9UQ84 Q96IJ1 Q9UG38 O75214 O60545 Q5T396 O75466 Q9UNW0
Accessions AAC32424 AAC69879 AAC69880 AAN39382 EAW70103 EAW70104 EAW70105 EAW70106 Q9UQ84 AF042282 AAC32259 AF060479 AAC33874 AF084974 AAD13754 AF091740 AAC63043 AK291291 BAF83980 AL080139 CAB45733 BC007491 AAH07491 BM465399 BM983504 CA430743 CD644038 CN348533 DA661516 DQ893032 ABM83958 EU176754 ABW03555 XM_005273350 XP_005273407 XM_006711840 XP_006711903 XM_011544321 XP_011542623 XM_011544322 XP_011542624 XM_011544323 XP_011542625 XM_011544324 XP_011542626 XM_011544325 XP_011542627 XM_011544326 XP_011542628 XM_011544327 XP_011542629 XR_949162 NM_003686 NP_003677 NM_006027 NP_006018 NM_130398 NP_569082
Function 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase.
Tissue Specificity Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. {ECO:0000269|PubMed:10856833, ECO:0000269|PubMed:9685493, ECO:0000269|PubMed:9788596, ECO:0000269|PubMed:9823303}.
Top Pathways Mismatch repair

Exo1 CRISPR/Cas9 KO Plasmid (h) - sc-402356 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 HDR Plasmid (h) - sc-402356-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 Double Nickase Plasmid (h) - sc-402356-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 Double Nickase Plasmid (h2) - sc-402356-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 CRISPR Activation Plasmid (h) - sc-402356-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 CRISPR Activation Plasmid (h2) - sc-402356-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 Lentiviral Activation Particles (h) - sc-402356-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 Lentiviral Activation Particles (h2) - sc-402356-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Exo1 siRNA (h) - sc-44880 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exo1 shRNA Plasmid (h) - sc-44880-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exo1 shRNA (h) Lentiviral Particles - sc-44880-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exonuclease 1 RNAi - H00009156-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Exonuclease 1 RNAi - H00009156-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU086301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8032 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8032 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03017 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03017

EXO1 siRNA (Human) - CRH6060 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Exonuclease 1 RNAi - H00009156-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EXO1 - MBS8217524 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EXO1 (NM_130398.3) - SHH287917 from Creative biogene

Category siRNA
Species Reactivities Human

Human EXO1 siRNA - orb266562 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXO1 shRNA Plasmid (Human) - CHH6060 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXO1 miRNA 3'UTR clone - MiUTR3H-08185 from Creative biogene

Species Reactivities Human

EXO1 miRNA 3'UTR clone - MiUTR3H-08186 from Creative biogene

Species Reactivities Human
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