EXO1

Gene Symbol EXO1
Entrez Gene 9156
Alt Symbol HEX1, hExoI
Species Human
Gene Type protein-coding
Description exonuclease 1
Other Description hExo1|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Swissprots Q9UQ84 Q96IJ1 Q9UG38 O75214 O60545 Q5T396 O75466 Q9UNW0
Accessions AAC32424 AAC69879 AAC69880 AAN39382 EAW70103 EAW70104 EAW70105 EAW70106 Q9UQ84 AF042282 AAC32259 AF060479 AAC33874 AF084974 AAD13754 AF091740 AAC63043 AK291291 BAF83980 AL080139 CAB45733 BC007491 AAH07491 BM465399 BM983504 CA430743 CD644038 CN348533 DA661516 DQ893032 ABM83958 EU176754 ABW03555 XM_005273350 XP_005273407 XM_006711840 XP_006711903 XM_011544321 XP_011542623 XM_011544322 XP_011542624 XM_011544323 XP_011542625 XM_011544324 XP_011542626 XM_011544325 XP_011542627 XM_011544326 XP_011542628 XM_011544327 XP_011542629 XR_949162 NM_003686 NP_003677 NM_006027 NP_006018 NM_130398 NP_569082
Function 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase.
Tissue Specificity Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. {ECO:0000269|PubMed:10856833, ECO:0000269|PubMed:9685493, ECO:0000269|PubMed:9788596, ECO:0000269|PubMed:9823303}.
Top Pathways Mismatch repair

Exo1 (N-18) - sc-19941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Exo1 (N-18): sc-19941. Western blot analysis of Exo1 expression in rat testis tissue extract.

Exo1 (H-300) - sc-33194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Exo1 (H-300): sc-33194. Western blot analysis of Exo1 expression in non-transfected: sc-117752 (A) and human Exo1 transfected: sc-171270 (B) 293T whole cell lysates and mouse testis tissue extract (C).

Exo1 (266) - sc-56092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Exo1 (266): sc-56092. Western blot analysis of Exo1 expression in mouse testis tissue extract.

Exo1 (SPM394) - sc-56387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Exo1 (SPM394): sc-56387. Western blot analysis of Exo1 expression in mouse testis tissue extract.

Anti-EXO1 antibody - ab82533 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-EXO1 antibody (ab82533) at 1/5000 dilutionLane 2 : Pre-immune seraLane 1 : Recombinant EXO1 (overloaded)Lane 2 : Recombinant EXO1 (overloaded)

Anti-Exonuclease 1 antibody - ab106303 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Exonuclease 1 antibody (ab106303) at 1/250 dilutionLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 3 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell LysateLane 4 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 5 : Bone Marrow (Human) Tissue Lysate - adult normal tissueLane 6 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lane 7 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Exonuclease 1 antibody - ab155553 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Exonuclease 1 antibody (ab155553) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-Exonuclease 1 antibody - ab69874 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Exonuclease 1 antibody (ab69874) at 1/500 dilutionLane 1 : Extracts from A549 cellsLane 2 : Extracts from A549 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Exonuclease 1 antibody - ab95012 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Exonuclease 1 antibody (ab95012) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Exonuclease 1 antibody - ab95068 from Abcam

Prices $370.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Exonuclease 1 antibody (ab95068) at 0.04 µg/mlLane 1 : Hela whole cell lysate at 50 µgLane 2 : Hela whole cell lysate at 15 µgLane 3 : Hela whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Exonuclease 1 antibody - ab77375 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Exonuclease 1 antibody (ab77375) at 0.2 µg/ml + A549 cell lysate (in RIPA buffer) at 35 µg

Anti-Exonuclease 1 antibody - ab111017 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111017, at 3.75µg/ml, staining Exonuclease 1 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

Anti-Exonuclease 1 antibody - ab56472 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Exonuclease 1 antibody - ab56064 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Exonuclease 1 antibody [266] - ab3307 from Abcam

Prices $370.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 266

Anti-Exonuclease 1 antibody - N-terminal - ab82314 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Exonuclease 1 antibody - N-terminal (ab82314) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

Anti-EXO1 Antibody - LS-C6742 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-EXO1 Antibody (N-Terminus) - LS-C46812 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EXO1 Antibody (clone 266, Azide-free) - LS-C87803 from LifeSpan Bioscience

Prices $620.00, $925.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone 266

Anti-EXO1 Antibody (clone 266) - LS-C87802 from LifeSpan Bioscience

Prices $295.00, $555.00, $850.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone 266

Anti-EXO1 Antibody (aa747-846, clone 10C180, Azide-free) - LS-C183610 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10C180

Anti-EXO1 Antibody (clone SPM179) - LS-C188995 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM179

Anti-EXO1 Antibody (aa372-383) - LS-C54802 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.2 ug/ml) staining of A549 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-EXO1 Antibody (aa74-123) - LS-C146178 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EXO1 antibody LS-C146178 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.

Anti-EXO1 Antibody (aa1-30) - LS-C97374 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-EXO1 Antibody in NCI-H460 cell line lysates (35 ug/lane). EXO1 (arrow) was detected using the purified antibody.
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