| Gene Symbol |
B3GALNT2
|
| Entrez Gene |
148789
|
| Alt Symbol |
B3GalNAc-T2, MDDGA11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beta-1,3-N-acetylgalactosaminyltransferase 2
|
| Other Description |
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2|UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2|beta-1,3-GalNAc-T2
|
| Swissprots |
Q96AL7 Q5TCI3 Q59GR3 Q8NCR0
|
| Accessions |
CAI21727 CAI21728 EAW70026 EAW70027 EAW70028 Q8NCR0 AB209046 BAD92283 AK091497 AK130297 AK311626 AW513183 BC016974 AAH16974 BC029564 AAH29564 BQ221255 XM_005273071 XP_005273128 XM_006711749 XP_006711812 XM_011544096 XP_011542398 XM_011544097 XP_011542399 NM_001277155 NP_001264084 NM_152490 NP_689703
|
| Function |
Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:14724282, ECO:0000269|PubMed:23453667, ECO:0000269|PubMed:23929950}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23453667}.
|
| Tissue Specificity |
Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary. {ECO:0000269|PubMed:14724282}.
|
