Gene Symbol | B3GALNT2 |
---|---|
Entrez Gene | 148789 |
Alt Symbol | B3GalNAc-T2, MDDGA11 |
Species | Human |
Gene Type | protein-coding |
Description | beta-1,3-N-acetylgalactosaminyltransferase 2 |
Other Description | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2|UDP-GalNAc:betaGlcNAc beta-1,3-galactosaminyltransferase, polypeptide 2|beta-1,3-GalNAc-T2 |
Swissprots | Q96AL7 Q5TCI3 Q59GR3 Q8NCR0 |
Accessions | CAI21727 CAI21728 EAW70026 EAW70027 EAW70028 Q8NCR0 AB209046 BAD92283 AK091497 AK130297 AK311626 AW513183 BC016974 AAH16974 BC029564 AAH29564 BQ221255 XM_005273071 XP_005273128 XM_006711749 XP_006711812 XM_011544096 XP_011542398 XM_011544097 XP_011542399 NM_001277155 NP_001264084 NM_152490 NP_689703 |
Function | Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:14724282, ECO:0000269|PubMed:23453667, ECO:0000269|PubMed:23929950}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23453667}. |
Tissue Specificity | Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary. {ECO:0000269|PubMed:14724282}. |
Anti-B3GALNT2 antibody - ab176869 from Abcam
|
||||||||||
Anti-B3GALNT2 antibody - ab90124 from Abcam
|
||||||||||
Anti-B3GALNT2 antibody - ab85502 from Abcam
|
||||||||||
Anti-B3GALNT2 antibody [1G2] - ab156785 from Abcam
|
||||||||||
Anti-B3GALNT2 Antibody (aa395-444) - LS-C111221 from LifeSpan Bioscience
|
||||||||||
Anti-B3GALNT2 Antibody (aa216-265) - LS-C102328 from LifeSpan Bioscience
|
||||||||||
Anti-B3GALNT2 Antibody (clone 1G2) - LS-C174618 from LifeSpan Bioscience
|
||||||||||
B3GALNT2 Antibody - NBP1-82699 from Novus Biologicals
|
||||||||||
B3GALNT2 Antibody - NBP1-57930 from Novus Biologicals
|
||||||||||
B3GALNT2 Antibody - NBP2-15532 from Novus Biologicals
|
||||||||||
Anti-B3GALNT2 antibody produced in rabbit - SAB2100193 from Sigma-Aldrich
|
||||||||||
Anti-B3GALNT2 antibody produced in rabbit - SAB2103675 from Sigma-Aldrich
|
||||||||||
Anti-B3GALNT2 antibody produced in rabbit - HPA012502 from Sigma-Aldrich
|
||||||||||
B3GALNT2 antibody - middle region (ARP49060_P050) - ARP49060_P050 from Aviva Systems Biology
|
||||||||||
B3GALNT2 antibody - middle region (ARP49061_P050) - ARP49061_P050 from Aviva Systems Biology
|
||||||||||
B3GALNT2 antibody [N1C2] - GTX121194 from GeneTex
|
||||||||||
Anti -B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2, MDDGA11, B3GalNAc-T2) - 209697 from USBiological Life Science
|
||||||||||
B3GALNT2 antibody - 70R-15943 from Fitzgerald
|
||||||||||
B3GALNT2 Polyclonal Antibody - A5171 from ABclonal
|
||||||||||
B3GALNT2 antibody - 70R-5327 from Fitzgerald
|
||||||||||
B3GALNT2 Antibody - abx003964 from Abbexa
|
||||||||||
B3GALNT2 Antibody - abx036701 from Abbexa
|
||||||||||
B3GALNT2 antibody - 17142-1-AP from Acris Antibodies
|
||||||||||
Anti-B3GALNT2, Polyclonal Antibody - 25-A5171 from ARP American Research Products
|
||||||||||
B3GALNT2 Antibody - 26-373 from ProSci
|