| Gene Symbol | FOXN1 |
|---|---|
| Entrez Gene | 8456 |
| Alt Symbol | FKHL20, RONU, WHN |
| Species | Human |
| Gene Type | protein-coding |
| Description | forkhead box N1 |
| Other Description | Rowett nude|forkhead box protein N1|winged helix nude|winged-helix nude|winged-helix transcription factor nude |
| Swissprots | B2R9Q7 O15353 O15352 |
| Accessions | CAA72417 EAW51092 O15353 AF086453 AK313878 BAG36604 BC140423 AAI40424 BC146539 AAI46540 Y11739 CAA72416 XM_005258046 XP_005258103 XM_011525354 XP_011523656 XM_011525355 XP_011523657 XM_011525356 XP_011523658 XM_011525357 XP_011523659 XM_011525358 XP_011523660 XM_011525359 XP_011523661 XM_011525360 XP_011523662 XM_011525361 XP_011523663 XM_011525362 XP_011523664 XM_011525363 XP_011523665 XM_011525364 XP_011523666 XM_011525365 XP_011523667 XM_011525366 XP_011523668 XM_011525367 XP_011523669 XM_011525368 XP_011523670 XM_011525369 XP_011523671 XM_011525370 XP_011523672 NM_003593 NP_003584 |
| Function | Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hemato |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed in thymus. |
FOXN1 overexpression lysate - LY418562 from Acris Antibodies
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Panoply™ Human FOXN1 Knockdown Stable Cell Line - CSC-DC005869 from Creative biogene
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