MUC4

Gene Symbol MUC4
Entrez Gene 4585
Alt Symbol ASGP, HSA276359, MUC-4
Species Human
Gene Type protein-coding
Description mucin 4, cell surface associated
Other Description ascites sialoglycoprotein|mucin 4, tracheobronchial|mucin-4|pancreatic adenocarcinoma mucin|testis mucin|tracheobronchial mucin
Swissprots Q9GZV6 Q9NY78 Q9NY81 Q9NPJ0 Q9H482 Q9NY80 Q9NY79 Q99102 O95938 Q9H4D6 Q9H486 Q9H485 Q9H4D8 Q9NY75 Q9H487 Q9H483 Q9H484 Q9H481 Q9NY76 Q9NY09 Q9GZM2 Q9NY77
Accessions AAK92019 AAM66747 CAD22550 Q99102 AF058803 AAC34750 AF058804 AAC34751 AF177925 AAD53171 AJ000281 CAA03985 AJ010901 CAB38059 AJ242541 CAB85597 AJ242542 CAB85598 AJ242543 CAB85599 AJ242544 CAB85600 AJ242545 CAB85601 AJ242546 CAB85602 AJ242547 CAB85603 AJ242548 CAB85604 AJ242549 CAB85605 AJ242550 CAB85606 AJ276359 CAB81773 AJ277412 CAC10061 AJ277505 CAC14585 AJ400633 CAC10062 AJ400849 CAC14134 AJ400850 CAC14135 AJ400851 CAC14136 AJ400852 CAC14137 AJ400853 CAC14138 AJ400854 CAC14139 AJ400855 CAC14140 AJ400856 CAC14141 AJ400857 CAC14142 AJ400858 CAC14143 AK074437 AK307054 AW190850 BC131770 BX957139 DB227644 EF091824 ABK78776 M64594 AAA63230 NM_004532 NP_004523 NM_018406 NP_060876 NM_138297 NP_612154 NM_138298 NM_138299
Function May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. {ECO:0000269|PubMed:12102554, ECO:0000269|PubMed:16049287, ECO:0000269|PubMe
Subcellular Location Isoform 17: Cell membrane; Single-pass membrane protein.
Tissue Specificity Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. {ECO:0000269|PubMed:10024507, ECO:0000269|PubMed:10880978, ECO:0000269|PubMed:10920259, ECO:0000269|PubMed:16814944}.

Epithelial sialomucin (140 C1) - sc-52329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl ascites
Host Mouse
Clonality Monoclonal

Mucin 4 (1G8) - sc-33654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mucin 4 (1G8): sc-33654. Western blot analysis of Mucin 4β expression in HUV-EC-C whole cell lysate.

Mucin 4 (8G7) - sc-53945 from Santa Cruz Biotechnology

Prices $295.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mucin 4 (8G7): sc-53945. Western blot analysis of Mucin 4 expression in Panc-1 (A), CD-18/HPAF (B) and Colo357 (C) cells showing glycosylation. Kindly provided by Dr. Surinder Batra, University of Nebraska Medical Center.

Mucin 4 (C-20) - sc-49763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Mucin 4 (H-300) - sc-20117 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mucin 4 (H-300): sc-20117. Western blot analysis of Mucin 4 expression in MCF7 (A), SW480 (B), HeLa (C) and SCC-4 (D) whole cell lysates.

Mucin 4 (P-20) - sc-16901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MUC4 antibody - ab60720 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-MUC4 antibody (ab60720) at 1 µg/ml + HeLa cell lysate at 25 µg

Anti-MUC4 antibody - ab76038 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MUC4 antibody (ab76038) at 1 µg/ml + PC3 (Human prostate carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MUC4 antibody [6A134] - ab85717 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 6A134
ab85717, at 20µg/ml, staining MUC4 in formalin-fixed, paraffin-embedded human colon tissue by Immunohistochemistry.A heat induced antigen retrieval step was performed using pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-MUC4 antibody [8G-7] - ab52263 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8G-7
IHC image of ab52263 staining in human pancreatic carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab52263, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-MUC4 antibody [EPR16237] - ab194363 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16237
All lanes : Anti-MUC4 antibody [EPR16237] (ab194363) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLane 3 : SW480 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-MUC4 antibody [EPR9308] - ab150381 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9308
Immunohistochemical analysis of paraffin embedded Human colon tissue labeling MUC4 with ab150381 at a 1/50 dilution.

Anti-MUC4 antibody [SP241] - C-terminal - ab183320 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP241
Immunohistochemical analysis of paraffin-embedded Human lung adenocarcinoma tissue labeling MUC4 with ab183320 at 1/100 dilution.

Anti-MUC4 Antibody (clone 1G8) - LS-C9121 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G8

Anti-MUC4 Antibody (clone 1D4B) - LS-C189741 from LifeSpan Bioscience

Prices $345.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal
Clone 1D4B

Anti-MUC4 Antibody (aa1154-1309, Biotin) - LS-C300967 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MUC4 Antibody (aa1154-1309, FITC) - LS-C303035 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MUC4 Antibody - LS-C340994 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MUC4 Antibody (C-Terminus, clone SP241) - LS-C210450 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µl
Host Rabbit
Clonality Monoclonal
Clone SP241
Immunohistochemistry of Human Lung adenocarcinoma stained with anti-MUC-4 antibody

Anti-MUC4 Antibody (aa1249-1444) - LS-C344004 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MUC4 antibody Western blot. All lanes: Anti MUC4 at 0.5 ug/ml. WB: PC12 Whole Cell Lysate at 40 ug. Predicted band size: 234 kD . Observed band size: 234 kD.

Anti-MUC4 Antibody (aa1154-1309) - LS-C295444 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant MUC4.

Anti-MUC4 Antibody (clone 5B12) - LS-C104999 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5B12
MUC4 monoclonal antibody (M07), clone 5B12 Western blot of MUC4 expression in HeLa.

Anti-MUC4 Antibody (clone EP256, Ready-to-Use) - LS-C348530 from LifeSpan Bioscience

Prices $265.00, $365.00, $620.00
Sizes 3 ml, 7 ml, 15 ml
Host Rabbit
Clonality Monoclonal
Clone EP256
IHC of Actin, Muscle-Specific on FFPE Skeletal Muscle Tissue.

Anti-MUC4 Antibody (aa1950-2100) IHC-plus™ - LS-B6781 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MUC4 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6781 concentration 5 ug/ml.

Anti-MUC4 Antibody (aa529-560) - LS-C344406 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from HeLa, MCF-7 cell line (from left to right) with MUC4 (Mucin-4 alpha chain) Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
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