MUC4
| Gene Symbol | MUC4 |
|---|---|
| Entrez Gene | 4585 |
| Alt Symbol | ASGP, HSA276359, MUC-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mucin 4, cell surface associated |
| Other Description | ascites sialoglycoprotein|mucin 4, tracheobronchial|mucin-4|pancreatic adenocarcinoma mucin|testis mucin|tracheobronchial mucin |
| Swissprots | Q9GZV6 Q9NY78 Q9NY81 Q9NPJ0 Q9H482 Q9NY80 Q9NY79 Q99102 O95938 Q9H4D6 Q9H486 Q9H485 Q9H4D8 Q9NY75 Q9H487 Q9H483 Q9H484 Q9H481 Q9NY76 Q9NY09 Q9GZM2 Q9NY77 |
| Accessions | AAK92019 AAM66747 CAD22550 Q99102 AF058803 AAC34750 AF058804 AAC34751 AF177925 AAD53171 AJ000281 CAA03985 AJ010901 CAB38059 AJ242541 CAB85597 AJ242542 CAB85598 AJ242543 CAB85599 AJ242544 CAB85600 AJ242545 CAB85601 AJ242546 CAB85602 AJ242547 CAB85603 AJ242548 CAB85604 AJ242549 CAB85605 AJ242550 CAB85606 AJ276359 CAB81773 AJ277412 CAC10061 AJ277505 CAC14585 AJ400633 CAC10062 AJ400849 CAC14134 AJ400850 CAC14135 AJ400851 CAC14136 AJ400852 CAC14137 AJ400853 CAC14138 AJ400854 CAC14139 AJ400855 CAC14140 AJ400856 CAC14141 AJ400857 CAC14142 AJ400858 CAC14143 AK074437 AK307054 AW190850 BC131770 BX957139 DB227644 EF091824 ABK78776 M64594 AAA63230 NM_004532 NP_004523 NM_018406 NP_060876 NM_138297 NP_612154 NM_138298 NM_138299 |
| Function | May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. {ECO:0000269|PubMed:12102554, ECO:0000269|PubMed:16049287, ECO:0000269|PubMe |
| Subcellular Location | Isoform 17: Cell membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. {ECO:0000269|PubMed:10024507, ECO:0000269|PubMed:10880978, ECO:0000269|PubMed:10920259, ECO:0000269|PubMed:16814944}. |
Mucin 4 CRISPR/Cas9 KO Plasmid (h) - sc-400329 from Santa Cruz Biotechnology
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Mucin 4 HDR Plasmid (h) - sc-400329-HDR from Santa Cruz Biotechnology
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Mucin 4 Double Nickase Plasmid (h) - sc-400329-NIC from Santa Cruz Biotechnology
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Mucin 4 Double Nickase Plasmid (h2) - sc-400329-NIC-2 from Santa Cruz Biotechnology
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Mucin 4 CRISPR Activation Plasmid (h) - sc-400329-ACT from Santa Cruz Biotechnology
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Mucin 4 CRISPR Activation Plasmid (h2) - sc-400329-ACT-2 from Santa Cruz Biotechnology
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Mucin 4 Lentiviral Activation Particles (h) - sc-400329-LAC from Santa Cruz Biotechnology
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Mucin 4 Lentiviral Activation Particles (h2) - sc-400329-LAC-2 from Santa Cruz Biotechnology
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Mucin 4 siRNA (h) - sc-43163 from Santa Cruz Biotechnology
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Mucin 4 shRNA Plasmid (h) - sc-43163-SH from Santa Cruz Biotechnology
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Mucin 4 shRNA (h) Lentiviral Particles - sc-43163-V from Santa Cruz Biotechnology
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Mucin 4 siRNA (h2) - sc-61703 from Santa Cruz Biotechnology
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Mucin 4 shRNA Plasmid (h2) - sc-61703-SH from Santa Cruz Biotechnology
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Mucin 4 shRNA (h2) Lentiviral Particles - sc-61703-V from Santa Cruz Biotechnology
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MUC-4 RNAi - H00004585-R01 from Novus Biologicals
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MUC-4 RNAi - H00004585-R03 from Novus Biologicals
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MUC-4 RNAi - H00004585-R02 from Novus Biologicals
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MISSION® esiRNA - EHU149571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14759 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14759 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03374 from Sigma-Aldrich
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MUC4 siRNA (Human) - CRH3021 from Cohesion Biosciences
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MUC-4 RNAi - H00004585-R04 from Novus Biologicals
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shRNA set against Human MUC4 (NM_004532.5) - SHH346944 from Creative biogene
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Mucin 4 CRISPR/Cas9 KO Plasmid (h2) - sc-400329-KO-2 from Santa Cruz Biotechnology
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