| Gene Symbol |
Asic1
|
| Entrez Gene |
79123
|
| Alt Symbol |
Accn2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
acid-sensing (proton-gated) ion channel 1
|
| Other Description |
BNaC2|acid-sensing ion channel 1|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2|proton gated cation channel ASIC1
|
| Swissprots |
O88762 P55926 Q91YB8 Q99NA1
|
| Accessions |
EDL86974 EDL86975 EDL86976 EDL86977 P55926 AB049451 BAB39864 AJ006519 CAA07080 AJ309926 CAC44267 CO398759 DV721841 XM_006257378 XP_006257440 XM_006257381 XP_006257443 XM_008765793 XP_008764015 XM_008765794 XP_008764016 XM_008765795 XP_008764017 XM_008765796 XP_008764018 NM_024154 NP_077068
|
| Function |
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:11448963, ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:12198124, ECO:0000269|Pu
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9707631}; Multi- pass membrane protein {ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9707631}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in dorsal root ganglia and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed in olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion (DRG) while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus. {ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9360943, ECO:0000269|PubMed:9707631}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|