Asic1

Gene Symbol Asic1
Entrez Gene 79123
Alt Symbol Accn2
Species Rat
Gene Type protein-coding
Description acid-sensing (proton-gated) ion channel 1
Other Description BNaC2|acid-sensing ion channel 1|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2|proton gated cation channel ASIC1
Swissprots O88762 P55926 Q91YB8 Q99NA1
Accessions EDL86974 EDL86975 EDL86976 EDL86977 P55926 AB049451 BAB39864 AJ006519 CAA07080 AJ309926 CAC44267 CO398759 DV721841 XM_006257378 XP_006257440 XM_006257381 XP_006257443 XM_008765793 XP_008764015 XM_008765794 XP_008764016 XM_008765795 XP_008764017 XM_008765796 XP_008764018 NM_024154 NP_077068
Function Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:11448963, ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:12198124, ECO:0000269|Pu
Subcellular Location Cell membrane {ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9707631}; Multi- pass membrane protein {ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9707631}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in dorsal root ganglia and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed in olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion (DRG) while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus. {ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:11842212, ECO:0000269|PubMed:9360943, ECO:0000269|PubMed:9707631}.
Top Pathways Inflammatory mediator regulation of TRP channels

ACCN1 Beta Antibody - NB300-188 from Novus Biologicals

Prices $229.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

ASIC1-Antibody - AG1389 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain membranes: 1. Anti-ASIC1 antibody (#AG1389), (1:200).    2. Anti-ASIC1 antibody, preincubated with the control peptide antigen.

Anti-ACCN2 (extracellular domain) polyclonal antibody - DPABH-29090 from Creative Diagnostics

Host Sheep
Clonality Polyclonal

Rabbit anti-Rat ACCN2 polyclonal antibody - DPABH-29105 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

ASIC1 Polyclonal Antibody - PA1-24648 from Thermo Fisher Scientific

Prices $375.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

ASIC1 Polyclonal Antibody - PA1-46418 from Thermo Fisher Scientific

Prices $309.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

ASIC1 Antibody - WGA1152 from WuXi Biosciences

Prices $275.00, $375.00, $475.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain membranes: 1. Anti-ASIC1 antibody (#WGA1152), (1:200). 2. Anti-ASIC1 antibody, preincubated with the control peptide antigen.

ASIC1 / ACCN2 antibody - TA329037 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat brain membranes: 1. Anti-ASIC1 antibody , (1:200). 2. Anti-ASIC1 antibody, preincubated with the control peptide antigen.

pan-ASIC-extracellular-Antibody - AG1595 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat dorsal root ganglion lysate (lanes 1 and 3) and rat brain membranes (lanes 2 and 4):1-2.Anti-pan ASIC (extracellular) antibody (#AG1595), (1:500).3 -4. Anti-pan ASIC (extracellular) antibody, preincubated with the control peptide antigen.
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