Gene Symbol | UCK2 |
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Entrez Gene | 7371 |
Alt Symbol | TSA903, UK, UMPK |
Species | Human |
Gene Type | protein-coding |
Description | uridine-cytidine kinase 2 |
Other Description | cytidine monophosphokinase 2|testis-specific protein TSA903|uridine kinase|uridine monophosphate kinase|uridine monophosphokinase 2 |
Swissprots | Q9BU42 Q5VV91 Q96KG5 Q7KZV3 Q92528 Q9BZX2 |
Accessions | CBN61306 CBN62649 CBN69656 EAW90767 EAW90768 EAW90769 Q9BZX2 AB062451 BAB56162 AF236637 AAK14053 AK294537 BAG57744 AK309739 BC002906 AAH02906 BM714864 BT006860 AAP35506 CR456857 CAG33138 D78335 BAA11349 DR762696 XM_011509969 XP_011508271 XM_011509970 XP_011508272 NM_012474 NP_036606 |
Function | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. |
Tissue Specificity | According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. {ECO:0000269|PubMed:8812458}. |
Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism |
UCK2 CRISPR/Cas9 KO Plasmid (h) - sc-408156 from Santa Cruz Biotechnology
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UCK2 HDR Plasmid (h) - sc-408156-HDR from Santa Cruz Biotechnology
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UCK2 Double Nickase Plasmid (h) - sc-408156-NIC from Santa Cruz Biotechnology
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UCK2 Double Nickase Plasmid (h2) - sc-408156-NIC-2 from Santa Cruz Biotechnology
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UCK2 CRISPR Activation Plasmid (h) - sc-408156-ACT from Santa Cruz Biotechnology
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UCK2 CRISPR Activation Plasmid (h2) - sc-408156-ACT-2 from Santa Cruz Biotechnology
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UCK2 Lentiviral Activation Particles (h) - sc-408156-LAC from Santa Cruz Biotechnology
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UCK2 Lentiviral Activation Particles (h2) - sc-408156-LAC-2 from Santa Cruz Biotechnology
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UCK2 siRNA (h) - sc-88781 from Santa Cruz Biotechnology
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UCK2 shRNA Plasmid (h) - sc-88781-SH from Santa Cruz Biotechnology
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UCK2 shRNA (h) Lentiviral Particles - sc-88781-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU153241 from Sigma-Aldrich
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MISSION® siRNA - SIHK2410 from Sigma-Aldrich
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MISSION® siRNA - SIHK2411 from Sigma-Aldrich
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MISSION® siRNA - SIHK2409 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22438 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22438 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02703 from Sigma-Aldrich
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UCK2 siRNA (Human) - CRH5041 from Cohesion Biosciences
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UCK2 RNAi - H00007371-R02 from Novus Biologicals
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UCK2 - MBS8232966 from MyBioSource
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shRNA set against Human UCK2 (NM_012474.4) - SHH439804 from Creative biogene
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Human UCK2 siRNA - orb265543 from Biorbyt
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UCK2 shRNA Plasmid (Human) - CHH5041 from Cohesion Biosciences
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UCK2 miRNA 3'UTR clone - MiUTR3H-10548 from Creative biogene
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