RTN3

Gene Symbol RTN3
Entrez Gene 10313
Alt Symbol ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
Species Human
Gene Type protein-coding
Description reticulon 3
Other Description ASY interacting protein|NSP-like protein 2|NSP-like protein II|homolog of ASY protein|neuroendocrine-specific protein-like 2|neuroendocrine-specific protein-like II|reticulon-3
Swissprots Q7RTM8 Q5UEP2 Q59EP0 B3KQS2 Q7RTM7 Q7RTN3 O95197 B7Z4M0 Q147U9 Q496K2 Q6T930 B7Z308 Q53GN3 F5H774
Accessions AAD20951 CAF32494 CAF32497 CAI72209 EAW74164 EAW74165 EAW74166 EAW74167 EAW74168 EAW74169 EAW74170 O95197 AB209771 BAD93008 AF059524 AAC99319 AF119297 AAD26810 AK075412 BAG52134 AK094965 AK122727 AK127079 AK222898 BAD96618 AK295361 BAH12044 AK295534 BAH12097 AK295758 BAH12179 AK297529 BAH12606 AK297533 BAH12607 AK304100 BAH14104 AK307811 AK308083 AK309766 AY427821 AAR02474 AY750848 AAU81930 BC000634 AAH00634 BC000865 AAH00865 BC010556 AAH10556 BC011394 AAH11394 BC022993 AAH22993 BC100822 AAI00823 BC100823 AAI00824 BC105981 AAI05982 BC105982 AAI05983 BC118550 AAI18551 BC118628 AAI18629 BC148632 AAI48633 BK001681 DAA01941 BK001682 DAA01942 BK001683 DAA01930 BK001684 DAA01943 BK001685 DAA01931 XM_011544730 XP_011543032 XM_011544731 XP_011543033 NM_001265589 NP_001252518 NM_001265590 NP_001252519 NM_001265591 NP_001252520 NM_006054 NP_006045 NM_201428 NP_958831 NM_201429 NP_958832 NM_201430 NP_958833 NR_049750 NR_049751
Function May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. {ECO:0000269|PubMed:10331947, ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:14986927, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:15946766}.

Rtn-3 (F-6) - sc-374599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rtn-3 (F-6): sc-374599. Western blot analysis of Rtn-3 expression in IMR-32 whole cell lysate.

Rtn-3 (C-19) - sc-16687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rtn-3 (H-90) - sc-33599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rtn-3 (H-90): sc-33599. Western blot analysis of Rtn-3 expression in IMR-32 whole cell lysate.

Anti-RTN3 antibody - ab172549 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-RTN3 antibody (ab172549) at 1 µg/mlLane 1 : RTN3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-RTN3 antibody - ab72814 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-RTN3 antibody - ab68328 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-RTN3 antibody (ab68328) at 1/500 dilutionLane 1 : RTN3 transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-RTN3 antibody [10A8] - ab86476 from Abcam

Host Mouse
Clonality Monoclonal
Clone 10A8
ab86476 at a 1/200 dilution staining RTN3 in human lung cancer tissue. DAB staining.

Anti-RTN3 antibody [1E11] - ab91186 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1E11
ab91186 at 1/200 dilution staining RTN3 in HeLa cells by Immunofluorescence (green). DRAQ5 fluorescent DNA dye (blue).

Anti-RTN3 antibody - C-terminal - ab187764 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RTN3 / Reticulon 3 Antibody (clone 10A8) IHC-plus™ - LS-B4116 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 10A8
Anti-RTN3 / Reticulon 3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4116 dilution 1:200.

Anti-RTN3 / Reticulon 3 Antibody (aa1017-1032) - LS-C313350 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RTN3 / Reticulon 3 antibody. IHC(P): Human Breast Cancer Tissue.

Anti-RTN3 / Reticulon 3 Antibody (N-Terminus) - LS-C144846 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RTN3 / Reticulon 3 Antibody - LS-C154770 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RTN3 / Reticulon 3 Antibody (clone 1E11) - LS-C109112 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E11
Confocal immunofluorescence of HeLa (A), A431 (B) and THP-1 (C) cells using RTN3 mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-RTN3 / Reticulon 3 Antibody (aa750-800) - LS-C289571 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Reticulon-3 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Reticulon-3 used at a dilution of 1:200 (1 ug/ml). Detection: Vector Laboratories ImmPACT NovaRED Peroxidase Substrate.

Anti-RTN3 / Reticulon 3 Antibody (aa550-600) - LS-C289568 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Reticulon-3 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Reticulon-3 antibody used for WB at 0.04 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 3 ug/mg lysate. Reticulon-3 was also immunoprecipitated by rabbit anti-Reticulon-3 antibody, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B).

RTN3 Antibody - NBP1-88871 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RTN3 Antibody [NBP1-88871] Staining of human cell line U-2 OS shows positivity in endoplasmic reticulum.

RTN3 Antibody (10A8) - NBP1-47353 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10A8
Immunohistochemistry-Paraffin: RTN3 Antibody (10A8) [NBP1-47353] - Immunohistochemical analysis of paraffin-embedded human Liver tissues using RTN3 mouse mAb

RTN3 Antibody - NBP1-88870 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: RTN3 Antibody [NBP1-88870] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

RTN3 Antibody (1E11) - NBP1-47448 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E11
Immunocytochemistry/Immunofluorescence: RTN3 Antibody (1E11) [NBP1-47448] - Confocal immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using anti-RTN3 monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.

RTN3 Antibody - H00010313-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RTN3 Antibody [H00010313-B01P] - analysis of RTN3 expression in transfected 293T cell line by RTN3 MaxPab polyclonal antibody. Lane 1: RTN3 transfected lysate (25.96 KDa). Lane 2: Non-transfected lysate.

RTN3 Antibody - H00010313-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RTN3 Antibody [H00010313-D01P] - Analysis of RTN3 expression in transfected 293T cell line by RTN3 polyclonal antibody.Lane 1: RTN3 transfected lysate(25.60 KDa).Lane 2: Non-transfected lysate.

NSPL2 Polyclonal Antibody - bs-7644R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RTN3 antibody produced in rabbit - HPA015650 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RTN3: <B>Cat. No. HPA015650</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex shows strong cytoplasmic positivity in neuronal cells and neuropil.

Monoclonal Anti-RTN3 antibody produced in mouse - SAB5300023 from Sigma-Aldrich

Prices $347.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10A8
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