RTN3

Gene Symbol RTN3
Entrez Gene 10313
Alt Symbol ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
Species Human
Gene Type protein-coding
Description reticulon 3
Other Description ASY interacting protein|NSP-like protein 2|NSP-like protein II|homolog of ASY protein|neuroendocrine-specific protein-like 2|neuroendocrine-specific protein-like II|reticulon-3
Swissprots Q7RTM8 Q5UEP2 Q59EP0 B3KQS2 Q7RTM7 Q7RTN3 O95197 B7Z4M0 Q147U9 Q496K2 Q6T930 B7Z308 Q53GN3 F5H774
Accessions AAD20951 CAF32494 CAF32497 CAI72209 EAW74164 EAW74165 EAW74166 EAW74167 EAW74168 EAW74169 EAW74170 O95197 AB209771 BAD93008 AF059524 AAC99319 AF119297 AAD26810 AK075412 BAG52134 AK094965 AK122727 AK127079 AK222898 BAD96618 AK295361 BAH12044 AK295534 BAH12097 AK295758 BAH12179 AK297529 BAH12606 AK297533 BAH12607 AK304100 BAH14104 AK307811 AK308083 AK309766 AY427821 AAR02474 AY750848 AAU81930 BC000634 AAH00634 BC000865 AAH00865 BC010556 AAH10556 BC011394 AAH11394 BC022993 AAH22993 BC100822 AAI00823 BC100823 AAI00824 BC105981 AAI05982 BC105982 AAI05983 BC118550 AAI18551 BC118628 AAI18629 BC148632 AAI48633 BK001681 DAA01941 BK001682 DAA01942 BK001683 DAA01930 BK001684 DAA01943 BK001685 DAA01931 XM_011544730 XP_011543032 XM_011544731 XP_011543033 NM_001265589 NP_001252518 NM_001265590 NP_001252519 NM_001265591 NP_001252520 NM_006054 NP_006045 NM_201428 NP_958831 NM_201429 NP_958832 NM_201430 NP_958833 NR_049750 NR_049751
Function May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. {ECO:0000269|PubMed:10331947, ECO:0000269|PubMed:12811824, ECO:0000269|PubMed:14986927, ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:15946766}.

Human RTN3 full length protein - ab153066 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153066 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human RTN3 protein fragment - ab153067 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153067 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human RTN3 Protein - H00010313-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

Recombinant Human RTN3 Protein - H00010313-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Reticulon-3 / RTN3 - H00010313-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

Reticulon-3 / RTN3 - H00010313-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Reticulon-3 / RTN3 - H00010313-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

RTN3 fusion protein - ag13766 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

RTN3 fusion protein - ag18764 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

RTN3 fusion protein - Ag2685 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human Reticulon-3(RTN3) ,partial - CSB-YP020570HU CSB-EP020570HU CSB-BP020570HU CSB-MP020570HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

RTN3 Recombinant Protein Antigen - NBP1-88871PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RTN3 Protein - NBP1-88870PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

RTN3 Peptide, Human - M34GP13674H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

RTN3 Antibody - SH-A15410 from Novatein Biosciences

Prices $315.00
Sizes 100 µl
Species Human, Mouse, Rat

Reticulon-3 (RTN3), Recombinant Protein - MBS1355695 from MyBioSource

Category Protein
Prices $990.00, $990.00, $1,210.00, $1,210.00, $1,495.00, $1,495.00, $1,960.00, $1,960.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Orangutan

Reticulon-3 (RTN3), partial, Recombinant Protein - MBS1029608 from MyBioSource

Category Protein
Prices $970.00, $970.00, $1,195.00, $1,195.00, $1,410.00, $1,410.00, $1,870.00, $1,870.00, $1,870.00, $2,745.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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