FGR

Gene Symbol FGR
Entrez Gene 2268
Alt Symbol SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr
Species Human
Gene Type protein-coding
Description FGR proto-oncogene, Src family tyrosine kinase
Other Description Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog|c-fgr protooncogene|c-src-2 proto-oncogene|feline Gardner-Rasheed sarcoma viral oncogene homolog|p55-c-fgr protein|proto-oncogene c-Fgr|proto-oncogene tyrosine-protein kinase FGR|tyrosine-protein kinase Fgr|v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Swissprots P09769 Q9UIQ3 D3DPL7
Accessions AAA52452 AAA52762 AAA60585 CAA36457 CAH05603 EAX07748 EAX07749 EAX07750 P09769 AK125143 AK130188 AK301078 BAH13403 AK304846 BAH14268 BC064382 AAH64382 BI771758 BQ448283 BX495937 DA139476 DA952771 DA960178 M19722 AAA52451 M27454 AAA35679 XM_006710452 XP_006710515 XM_011541010 XP_011539312 XM_011541011 XP_011539313 XM_011541012 XP_011539314 XM_011541013 XP_011539315 XM_011541014 XP_011539316 XR_946583 NM_001042729 NP_001036194 NM_001042747 NP_001036212 NM_005248 NP_005239
Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration a
Subcellular Location Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}.
Tissue Specificity Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. {ECO:0000269|PubMed:11078731, ECO:0000269|PubMed:2181286, ECO:0000269|PubMed:8327512}.
Top Pathways Chemokine signaling pathway, Epstein-Barr virus infection

Fgr Antibody - 2755 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raji cell lysate, using Fgr Antibody.

Phospho-Fgr (Tyr412) Antibody - 4111 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

c-Src (SRC 2) - sc-18 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Src p60 expression in WEHI-231 (A) and NIH/3T3 transformed with Src (B,C). Antibodies tested include c-Src (SRC 2): sc-18 (A), c-Src (N-16): sc-19 (B) and c-Src (B-12): sc-8056 (C).

c-Fgr (B-8) - sc-166079 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Fgr (B-8): sc-166079. Western blot analysis of c-Fgr expression in EB1 (A) and NAMALWA (B) whole cell lysates.

c-Fgr (C-11) - sc-514251 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Fgr (C-11): sc-514251. Western blot analysis of c-Fgr expression in EB1 (A) and NAMALWA (B) whole cell lysates.

c-Fgr (C-1) - sc-17 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Fgr (C-1): sc-17. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of smooth muscle cells.

c-Fgr (N-47) - sc-130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Fgr (N-47): sc-130. Western blot analysis of a human recombinant c-Fgr fusion protein.

c-Fgr (H-75) - sc-50337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Fgr (H-75): sc-50337. Western blot analysis of a human recombinant c-Fgr fusion protein.

Anti-FGR antibody - ab79357 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGR antibody (ab79357) at 1/500 dilutionLane 1 : Extracts from RAW264.7 cells Lane 2 : Extracts from RAW264.7 cells with immunizing peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-FGR antibody - ab58228 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
FGR antibody (ab58228) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lymph node.

Anti-FGR antibody - ab65007 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGR antibody (ab65007) at 1/500 dilutionLane 1 : Extracts from HUVEC cellsLane 2 : Extracts from COLO205 cellsLane 3 : Extracts from COLO205 cells with immunizing peptideLysates/proteins at 5 µg per lane.

Anti-FGR antibody - ab815 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
staining (0.5µg/ml) of Mouse Spleen extracts (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-FGR antibody - ab14468 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGR antibody [6G2] - ab81599 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6G2
All lanes : Anti-FGR antibody [6G2] (ab81599) at 1/500 dilutionLane 1 : HL60 cell lysate Lane 2 : Raw264.7 cell lysate

Anti-FGR antibody [EPR3170] - ab92302 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3170
All lanes : Anti-FGR antibody [EPR3170] (ab92302) at 1/1000 dilutionLane 1 : HL-60 cell lysate treated with retinoic acidLane 2 : Raji cell lysateLane 3 : PBMC cell lysateLysates/proteins at 10 µg per lane.

Anti-FGR antibody [EPR3171] - ab133349 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3171
Anti-FGR antibody [EPR3171] (ab133349) at 1/1000 dilution + Raji cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-FGR antibody - Aminoterminal end - ab71680 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FGR antibody - Aminoterminal end (ab71680) at 1/100 dilution + Ramos cell lysate at 12.5 µg

Anti-FGR Antibody (Internal, clone EPR3170) - LS-C105578 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3170
Western blot analysis on (A) HL-60 treated with Retinoic acid (B) Raji and (C) PBMC cell lysates using anti-FGR antibody (LS-C105578).

Anti-FGR Antibody (aa517-529) - LS-C54837 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (0.5 ug/ml) of Mouse Spleen extracts (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-FGR Antibody (C-Terminus) - LS-C116584 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FGR antibody LS-C116584 Western blot of U937 cell lysate.

Anti-FGR Antibody (aa61-110) - LS-C118770 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HUVEC/COLO205 cells, using FGR Antibody. The lane on the right is treated with the synthesized peptide.

Anti-FGR Antibody (clone 6G2) IHC-plus™ - LS-B4106 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 6G2
Anti-FGR antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4106 dilution 1:200.

Anti-FGR Antibody (N-Terminus, AP) - LS-C277336 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FGR Antibody (C-Terminus, clone EPR3171) - LS-C137703 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3171
Western blot analysis on Raji cell lysate using anti-Fgr antibody.

Anti-FGR Antibody (N-Terminus, APC) - LS-C277337 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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