| Gene Symbol | FGR |
|---|---|
| Entrez Gene | 2268 |
| Alt Symbol | SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr |
| Species | Human |
| Gene Type | protein-coding |
| Description | FGR proto-oncogene, Src family tyrosine kinase |
| Other Description | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog|c-fgr protooncogene|c-src-2 proto-oncogene|feline Gardner-Rasheed sarcoma viral oncogene homolog|p55-c-fgr protein|proto-oncogene c-Fgr|proto-oncogene tyrosine-protein kinase FGR|tyrosine-protein kinase Fgr|v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog |
| Swissprots | P09769 Q9UIQ3 D3DPL7 |
| Accessions | AAA52452 AAA52762 AAA60585 CAA36457 CAH05603 EAX07748 EAX07749 EAX07750 P09769 AK125143 AK130188 AK301078 BAH13403 AK304846 BAH14268 BC064382 AAH64382 BI771758 BQ448283 BX495937 DA139476 DA952771 DA960178 M19722 AAA52451 M27454 AAA35679 XM_006710452 XP_006710515 XM_011541010 XP_011539312 XM_011541011 XP_011539313 XM_011541012 XP_011539314 XM_011541013 XP_011539315 XM_011541014 XP_011539316 XR_946583 NM_001042729 NP_001036194 NM_001042747 NP_001036212 NM_005248 NP_005239 |
| Function | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration a |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}. |
| Tissue Specificity | Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. {ECO:0000269|PubMed:11078731, ECO:0000269|PubMed:2181286, ECO:0000269|PubMed:8327512}. |
| Top Pathways | Chemokine signaling pathway, Epstein-Barr virus infection |
c-Fgr CRISPR/Cas9 KO Plasmid (h) - sc-400702 from Santa Cruz Biotechnology
|
||||||||
c-Fgr HDR Plasmid (h) - sc-400702-HDR from Santa Cruz Biotechnology
|
||||||||
c-Fgr Double Nickase Plasmid (h) - sc-400702-NIC from Santa Cruz Biotechnology
|
||||||||
c-Fgr Double Nickase Plasmid (h2) - sc-400702-NIC-2 from Santa Cruz Biotechnology
|
||||||||
c-Fgr CRISPR Activation Plasmid (h) - sc-400702-ACT from Santa Cruz Biotechnology
|
||||||||
c-Fgr CRISPR Activation Plasmid (h2) - sc-400702-ACT-2 from Santa Cruz Biotechnology
|
||||||||
c-Fgr Lentiviral Activation Particles (h) - sc-400702-LAC from Santa Cruz Biotechnology
|
||||||||
c-Fgr Lentiviral Activation Particles (h2) - sc-400702-LAC-2 from Santa Cruz Biotechnology
|
||||||||
c-Fgr siRNA (h) - sc-39229 from Santa Cruz Biotechnology
|
||||||||
c-Fgr shRNA Plasmid (h) - sc-39229-SH from Santa Cruz Biotechnology
|
||||||||
c-Fgr shRNA (h) Lentiviral Particles - sc-39229-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU056441 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0792 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0795 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0796 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0793 from Sigma-Aldrich
|
||||||||
MISSION® siRNA - SIHK0794 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8677 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8677 from Sigma-Aldrich
|
||||||||
FGR siRNA (Human) - CRH1587 from Cohesion Biosciences
|
||||||||
Fgr RNAi - H00002268-R02 from Novus Biologicals
|
||||||||
FGR - MBS8207879 from MyBioSource
|
||||||||
c-Fgr CRISPR/Cas9 KO Plasmid (h2) - sc-400702-KO-2 from Santa Cruz Biotechnology
|
||||||||
c-Fgr HDR Plasmid (h2) - sc-400702-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human FGR (NM_005248.2) - SHH294785 from Creative biogene
|