| Gene Symbol | FOXA3 |
|---|---|
| Entrez Gene | 3171 |
| Alt Symbol | FKHH3, HNF3G, TCF3G |
| Species | Human |
| Gene Type | protein-coding |
| Description | forkhead box A3 |
| Other Description | HNF-3-gamma|HNF-3G|TCF-3G|fork head-related protein FKH H3|forkhead box protein A3|hepatocyte nuclear factor 3, gamma|hepatocyte nuclear factor 3-gamma|transcription factor 3G |
| Swissprots | A9LYI5 P55318 Q53F16 Q9UMW9 |
| Accessions | AAD51980 ABX44664 EAW57394 EAW57395 P55318 AK223473 BAD97193 BC016024 AAH16024 BT006720 AAP35366 L12141 AAA58477 NM_004497 NP_004488 |
| Function | Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269|PubMed:12695546}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:19706729}. |
| Tissue Specificity | Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined. {ECO:0000269|PubMed:8499623}. |
| Top Pathways | Maturity onset diabetes of the young |