CBS

Gene Symbol	CBS
Entrez Gene	875
Alt Symbol	HIP4
Species	Human
Gene Type	protein-coding
Description	cystathionine-beta-synthase
Other Description	beta-thionase|cystathionine beta-synthase|methylcysteine synthase|serine sulfhydrase
Swissprots	P35520 D3DSK4 Q99425 B2R993 Q9BWC5
Accessions	AAC64683 AAC64684 ABA28318 BAD90968 CAA61252 CAG14912 CBF70474 CBF85738 CBF88264 CBF94917 CBF99203 CBG07230 CBU94756 CBV01862 CBV02957 CBV08437 CBV12723 CBV20752 EAX09507 EAX09508 EAX09509 EAX09510 EAX09511 EAX09512 EAX09513 EAX09514 EAX09515 P35520 AK294608 BAH11822 AK301063 BAH13401 AK313691 BAG36440 AL137314 CAB70691 AL531222 BC000440 AAH00440 BC007257 AAH07257 BC010242 AAH10242 BC011381 AAH11381 BC012319 AAH12319 BT007154 AAP35818 DC300040 DQ891029 ABM81955 DQ894208 ABM85134 L00972 L14577 AAA98524 L19501 AAA19874 X82166 CAA57656 XM_011529773 XP_011528075 XM_011529774 XP_011528076 XM_011529775 XP_011528077 XM_011529776 XP_011528078 XM_011529777 XP_011528079 XM_011529778 XP_011528080 XM_011529779 XP_011528081 XM_011529781 XP_011528083 XM_011529782 XP_011528084 XM_011529783 XP_011528085 XM_011529784 XP_011528086 NM_000071 NP_000062 NM_001178008 NP_001171479 NM_001178009 NP_001171480
Function	Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17087506}. Nucleus {ECO:0000269|PubMed:17087506}.
Tissue Specificity	In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Top Pathways	Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Biosynthesis of amino acids

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CBS CRISPR/Cas9 KO Plasmid (h) - sc-400877 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS HDR Plasmid (h) - sc-400877-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS Double Nickase Plasmid (h) - sc-400877-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS Double Nickase Plasmid (h2) - sc-400877-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS CRISPR Activation Plasmid (h) - sc-400877-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS CRISPR Activation Plasmid (h2) - sc-400877-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS Lentiviral Activation Particles (h) - sc-400877-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS Lentiviral Activation Particles (h2) - sc-400877-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS siRNA (h) - sc-60335 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CBS shRNA Plasmid (h) - sc-60335-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CBS shRNA (h) Lentiviral Particles - sc-60335-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CBS RNAi - H00000875-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CBS RNAi - H00000875-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU099041 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5419 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5419 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06098 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06098

CBS siRNA (Human) - CRH0618 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CBS - MBS8230781 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CBS (NM_000071.2) - SHH255445 from Creative biogene Category siRNA Species Reactivities Human

CBS CRISPR/Cas9 KO Plasmid (h2) - sc-400877-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CBS HDR Plasmid (h2) - sc-400877-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human CBS siRNA - orb261120 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CBS shRNA Plasmid (Human) - CHH0618 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CBS miRNA 3'UTR clone - MiUTR3H-12872 from Creative biogene Species Reactivities Human

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