CBS

Gene Symbol CBS
Entrez Gene 875
Alt Symbol HIP4
Species Human
Gene Type protein-coding
Description cystathionine-beta-synthase
Other Description beta-thionase|cystathionine beta-synthase|methylcysteine synthase|serine sulfhydrase
Swissprots P35520 D3DSK4 Q99425 B2R993 Q9BWC5
Accessions AAC64683 AAC64684 ABA28318 BAD90968 CAA61252 CAG14912 CBF70474 CBF85738 CBF88264 CBF94917 CBF99203 CBG07230 CBU94756 CBV01862 CBV02957 CBV08437 CBV12723 CBV20752 EAX09507 EAX09508 EAX09509 EAX09510 EAX09511 EAX09512 EAX09513 EAX09514 EAX09515 P35520 AK294608 BAH11822 AK301063 BAH13401 AK313691 BAG36440 AL137314 CAB70691 AL531222 BC000440 AAH00440 BC007257 AAH07257 BC010242 AAH10242 BC011381 AAH11381 BC012319 AAH12319 BT007154 AAP35818 DC300040 DQ891029 ABM81955 DQ894208 ABM85134 L00972 L14577 AAA98524 L19501 AAA19874 X82166 CAA57656 XM_011529773 XP_011528075 XM_011529774 XP_011528076 XM_011529775 XP_011528077 XM_011529776 XP_011528078 XM_011529777 XP_011528079 XM_011529778 XP_011528080 XM_011529779 XP_011528081 XM_011529781 XP_011528083 XM_011529782 XP_011528084 XM_011529783 XP_011528085 XM_011529784 XP_011528086 NM_000071 NP_000062 NM_001178008 NP_001171479 NM_001178009 NP_001171480
Function Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17087506}. Nucleus {ECO:0000269|PubMed:17087506}.
Tissue Specificity In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Top Pathways Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Biosynthesis of amino acids

CBS (G-1) - sc-271886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBS (G-1): sc-271886. Western blot analysis of CBS expression in Hep G2 (A) and HeLa (B) whole cell lysates.

CBS (B-4) - sc-133154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBS (B-4): sc-133154. Western blot analysis of CBS expression in non-transfected 293T: sc-117752 (A), human CBS transfected 293T: sc-112304 (B) and HeLa (C) whole cell lysates and rat liver tissue extract (D).

CBS (H-300) - sc-67154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBS (H-300): sc-67154. Western blot analysis of CBS expression in non-transfected: sc-110760 (A) and human CBS transfected: sc-112304 (B) 293 whole cell lysates.

CBS (K-15) - sc-46831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBS (K-15): sc-46831. Western blot analysis of CBS expression in C6 whole cell lysate.

CBS (A-2) - sc-133208 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBS (A-2): sc-133208. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of glandular cells.

CBS (K-14) - sc-46830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBS (K-14): sc-46830. Western blot analysis of CBS expression in non-transfected: sc-110760 (A) and human CBS transfected: sc-112304 (B) 293 whole cell lysates.

CBS (N-13) - sc-46832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CBS (N-13): sc-46832. Western blot analysis of CBS expression in non-transfected: sc-110760 (A) and human CBS transfected: sc-112304 (B) 293 whole cell lysates.

Anti-CBS antibody - ab96252 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CBS antibody (ab96252) at 1/5000 dilutionLane 1 : Molt-4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-CBS antibody - ab135626 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CBS antibody (ab135626) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

Anti-CBS antibody - ab54883 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
CBS antibody (ab54883) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human hepatocellular carcinoma.

Anti-CBS antibody - ab126320 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab126320 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab126320 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CBS antibody - ab88437 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CBS antibody (ab88437) at 1 µg/ml + human liver tissue lysate at 25 µgdeveloped using the ECL technique

Anti-CBS antibody [3E1] - ab124276 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3E1
Anti-CBS antibody [3E1] (ab124276) at 1/500 dilution + HeLa cell lysate

Anti-CBS antibody [EPR8578] - ab131155 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8578
All lanes : Anti-CBS antibody [EPR8578] (ab131155) at 1/1000 dilutionLane 1 : Fetal liver lysateLane 2 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-CBS antibody [EPR8579] - ab140600 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8579
All lanes : Anti-CBS antibody [EPR8579] (ab140600) at 1/1000 dilutionLane 1 : Human fetal liver cell lysateLane 2 : Raji cell lysateLane 3 : HeLa cell lysateLane 4 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CBS antibody [GT519] - ab184219 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT519
Anti-CBS antibody [GT519] (ab184219) at 1/1000 dilution + rat liver lysate/extract at 50 µg

Anti-CBS Antibody (clone 3E1) IHC-plus™ - LS-B6016 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3E1
Anti-CBS antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6016 concentration 5 ug/ml.

Anti-CBS Antibody (aa39-251) - LS-C186298 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded OVCAR3 xenograft using CBS antibody at 1:500 dilution.

Anti-CBS Antibody (aa322-342) - LS-C312700 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CBS antibody. IHC(P): Human Liver Cancer Tissue.

Anti-CBS Antibody - LS-C331462 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat kidney using CBS antibody at dilution of 1:100 (400x lens).

Anti-CBS Antibody (clone 6A9) IHC-plus™ - LS-B6018 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6A9
Anti-CBS antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6018 concentration 5 ug/ml.

Anti-CBS Antibody (aa301-330) - LS-C168358 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with CBS Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CBS Antibody (clone 5F7) IHC-plus™ - LS-B6019 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5F7
Anti-CBS antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6019 concentration 5 ug/ml.

Anti-CBS Antibody (clone 6B8) IHC-plus™ - LS-B6017 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6B8
Anti-CBS antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6017 concentration 5 ug/ml.

Anti-CBS Antibody (N-Terminus, clone EPR8578) - LS-C154538 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8578
Western blot analysis on (A) fetal liver and (B) Raji cell lysates using anti-CBS antibody.
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