Gene Symbol | AHSP |
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Entrez Gene | 51327 |
Alt Symbol | EDRF, ERAF |
Species | Human |
Gene Type | protein-coding |
Description | alpha hemoglobin stabilizing protein |
Other Description | alpha hemoglobin stabilising protein|alpha-hemoglobin-stabilizing protein|erythroid associated factor|erythroid differentiation associated factor|erythroid differentiation-related factor|erythroid-associated factor |
Swissprots | Q8TD01 Q9NZD4 |
Accessions | AAL82894 AAO49381 EAW52118 Q9NZD4 AF112995 AAP97228 AF147435 AF208865 AAF64279 AF364517 AAK50856 BC035842 AAH35842 DQ890925 ABM81851 DQ894076 ABM85002 H94920 XM_005255351 XP_005255408 XM_005255352 XP_005255409 NM_016633 NP_057717 |
Function | Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. {ECO:0000269|PubMed:12066189}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12066189}. |
Tissue Specificity | Expressed in blood and bone marrow. {ECO:0000269|PubMed:11231637, ECO:0000269|PubMed:12066189}. |
AHSP CRISPR/Cas9 KO Plasmid (h) - sc-416422 from Santa Cruz Biotechnology
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AHSP HDR Plasmid (h) - sc-416422-HDR from Santa Cruz Biotechnology
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AHSP Double Nickase Plasmid (h) - sc-416422-NIC from Santa Cruz Biotechnology
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AHSP Double Nickase Plasmid (h2) - sc-416422-NIC-2 from Santa Cruz Biotechnology
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AHSP CRISPR Activation Plasmid (h) - sc-416422-ACT from Santa Cruz Biotechnology
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AHSP CRISPR Activation Plasmid (h2) - sc-416422-ACT-2 from Santa Cruz Biotechnology
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AHSP Lentiviral Activation Particles (h) - sc-416422-LAC from Santa Cruz Biotechnology
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AHSP Lentiviral Activation Particles (h2) - sc-416422-LAC-2 from Santa Cruz Biotechnology
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AHSP siRNA (h) - sc-60137 from Santa Cruz Biotechnology
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AHSP shRNA Plasmid (h) - sc-60137-SH from Santa Cruz Biotechnology
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AHSP shRNA (h) Lentiviral Particles - sc-60137-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2977 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2977 from Sigma-Aldrich
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AHSP siRNA (Human) - CRH9702 from Cohesion Biosciences
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ERAF RNAi - H00051327-R01 from Novus Biologicals
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AHSP - MBS8218506 from MyBioSource
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Human AHSP siRNA - orb270204 from Biorbyt
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AHSP shRNA Plasmid (Human) - CHH9702 from Cohesion Biosciences
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