NCDN
| Gene Symbol | NCDN |
|---|---|
| Entrez Gene | 23154 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | neurochondrin |
| Other Description | - |
| Swissprots | Q9UBY2 Q9UBB6 Q9Y4D9 D3DPR9 Q9Y4A6 |
| Accessions | AAD05029 BAA77830 BAA77831 EAX07410 EAX07411 EAX07412 Q9UBB6 AB011179 BAA25533 AB018739 BAA85384 AB018740 BAA85385 AK293658 BAG57106 AK295979 BAG58754 AL536768 AW207151 BC024592 AAH24592 BI545092 DQ891150 ABM82076 DQ894330 ABM85256 NM_001014839 NP_001014839 NM_001014841 NP_001014841 NM_014284 NP_055099 |
| Function | Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:16945926}. |
| Subcellular Location | Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons. |
| Tissue Specificity | Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine. {ECO:0000269|PubMed:10524216, ECO:0000269|PubMed:9628581}. |
NCDN CRISPR/Cas9 KO Plasmid (h) - sc-407770 from Santa Cruz Biotechnology
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NCDN HDR Plasmid (h) - sc-407770-HDR from Santa Cruz Biotechnology
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NCDN Double Nickase Plasmid (h) - sc-407770-NIC from Santa Cruz Biotechnology
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NCDN Double Nickase Plasmid (h2) - sc-407770-NIC-2 from Santa Cruz Biotechnology
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NCDN CRISPR Activation Plasmid (h) - sc-407770-ACT from Santa Cruz Biotechnology
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NCDN CRISPR Activation Plasmid (h2) - sc-407770-ACT-2 from Santa Cruz Biotechnology
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NCDN Lentiviral Activation Particles (h) - sc-407770-LAC from Santa Cruz Biotechnology
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NCDN Lentiviral Activation Particles (h2) - sc-407770-LAC-2 from Santa Cruz Biotechnology
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NCDN siRNA (h) - sc-78668 from Santa Cruz Biotechnology
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NCDN shRNA Plasmid (h) - sc-78668-SH from Santa Cruz Biotechnology
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NCDN shRNA (h) Lentiviral Particles - sc-78668-V from Santa Cruz Biotechnology
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Neurochondrin RNAi - H00023154-R02 from Novus Biologicals
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MISSION® esiRNA - EHU082931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15011 from Sigma-Aldrich
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NCDN siRNA (Human) - CRH8039 from Cohesion Biosciences
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Neurochondrin RNAi - H00023154-R03 from Novus Biologicals
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Neurochondrin RNAi - H00023154-R01 from Novus Biologicals
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shRNA set against Human NCDN (NM_014284.2) - SHH349912 from Creative biogene
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shRNA set against Human NCDN(NM_001014841.1) - SHR000420 from Creative biogene
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shRNA set against Human NCDN(NM_001014839.1) - SHR000456 from Creative biogene
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Human NCDN siRNA - orb268541 from Biorbyt
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NCDN shRNA Plasmid (Human) - CHH8039 from Cohesion Biosciences
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NCDN miRNA 3'UTR clone - MiUTR1H-06670 from Creative biogene
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NCDN miRNA 3'UTR clone - MiUTR1H-06671 from Creative biogene
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