| Gene Symbol |
TFDP3
|
| Entrez Gene |
51270
|
| Alt Symbol |
CT30, DP4, HCA661
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor Dp family, member 3
|
| Other Description |
E2F-like protein|cancer/testis antigen 30|hepatocellular carcinoma-associated antigen 661|transcription factor Dp family member 3
|
| Swissprots |
Q5H9I0 Q6DK49 Q9NZ54
|
| Accessions |
EAX11773 Q5H9I0 AF219119 AAF37562 BC074762 BC117336 BC126361 EU446842 ABZ92371 NM_016521 NP_057605
|
| Function |
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. {ECO:0000269|PubMed:16418725, ECO:0000269|PubMed:17062573, ECO:0000269|PubMed:20559320}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
|
| Tissue Specificity |
Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:16418725}.
|