TRPM2

Gene Symbol TRPM2
Entrez Gene 7226
Alt Symbol EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 2
Other Description LTrpC-2|estrogen-responsive element-associated gene 1 protein|long transient receptor potential channel 2|transient receptor potential cation channel subfamily M member 2|transient receptor potential channel 7
Swissprots Q5KTC2 Q6J3P5 Q96KN6 O94759 Q96Q93 D3DSL6
Accessions AAY22174 BAA95563 EAX09426 EAX09427 EAX09428 O94759 AB001535 BAA34700 AB017549 BAB64300 AB166745 BAD83705 AB166746 BAD83706 AJ417076 CAD01139 AJ878416 CAI47593 AK301101 BAG62700 AK301451 BAG62975 AY603182 AAT12288 BC041570 BC112342 AAI12343 BI755424 BI906484 EU362987 ACA62700 R85260 XM_005261171 XP_005261228 XM_006724049 XP_006724112 XM_011529734 XP_011528036 XM_011529735 XP_011528037 XM_011529736 XP_011528038 XM_011529737 XP_011528039 XR_937565 XR_937566 NM_003307 NP_003298 NR_038257 NM_001001188
Function Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. {ECO:0000269|PubMed:11804595}.
Subcellular Location Membrane {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:12594222}.
Tissue Specificity Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734}.
Top Pathways Oxytocin signaling pathway

TRPM2 (H-86) - sc-368395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TRPM2 (N-14) - sc-19198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRPM2 antibody - ab11168 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IHC image of ab11168 staining in rat brain formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab11168, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TRPM2 antibody - ab11167 from Abcam

Prices $379.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab11167 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab11167, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TRPM2 antibody - ab96785 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TRPM2 antibody (ab96785) at 1/500 dilution + HepG2 whole cell lysate at 30 µg

Anti-TRPM2 antibody - ab101738 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 antibody - ab62988 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPM2 antibody - ab83901 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM2 antibody (ab83901) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TRPM2 Antibody (aa1213-1265) - LS-C89808 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody - LS-C10881 from LifeSpan Bioscience

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody - LS-C89809 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (C-Terminus, DY488) - LS-C141846 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (C-Terminus, Biotin) - LS-C141844 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (Internal, Biotin) - LS-C141856 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (C-Terminus, DY650) - LS-C141845 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (C-Terminus, DY550) - LS-C141848 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (C-Terminus, HRP) - LS-C141847 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (Internal, DY650) - LS-C141857 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (Internal, HRP) - LS-C141859 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (Internal, DY488) - LS-C141858 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (aa1200-1250) - LS-C287306 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (aa650-700) - LS-C287307 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody (Internal, DY550) - LS-C141860 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody - LS-C341936 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM2 Antibody - LS-C346101 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using TRPM2 antibody. Blue: DAPI for nuclear staining.
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