| Gene Symbol |
TRPM2
|
| Entrez Gene |
7226
|
| Alt Symbol |
EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 2
|
| Other Description |
LTrpC-2|estrogen-responsive element-associated gene 1 protein|long transient receptor potential channel 2|transient receptor potential cation channel subfamily M member 2|transient receptor potential channel 7
|
| Swissprots |
Q5KTC2 Q6J3P5 Q96KN6 O94759 Q96Q93 D3DSL6
|
| Accessions |
AAY22174 BAA95563 EAX09426 EAX09427 EAX09428 O94759 AB001535 BAA34700 AB017549 BAB64300 AB166745 BAD83705 AB166746 BAD83706 AJ417076 CAD01139 AJ878416 CAI47593 AK301101 BAG62700 AK301451 BAG62975 AY603182 AAT12288 BC041570 BC112342 AAI12343 BI755424 BI906484 EU362987 ACA62700 R85260 XM_005261171 XP_005261228 XM_006724049 XP_006724112 XM_011529734 XP_011528036 XM_011529735 XP_011528037 XM_011529736 XP_011528038 XM_011529737 XP_011528039 XR_937565 XR_937566 NM_003307 NP_003298 NR_038257 NM_001001188
|
| Function |
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. {ECO:0000269|PubMed:11804595}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:12594222}.
|
| Tissue Specificity |
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734}.
|
| Top Pathways |
Oxytocin signaling pathway
|