CCL5

Gene Symbol	CCL5
Entrez Gene	6352
Alt Symbol	D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) ligand 5
Other Description	C-C motif chemokine 5|T-cell specific protein p288|beta-chemokine RANTES|eosinophil chemotactic cytokine|regulated upon activation, normally T-expressed, and presumably secreted|small inducible cytokine subfamily A (Cys-Cys), member 5
Swissprots	Q4ZGJ1 Q9UBG2 O43646 Q9UC99 P13501 Q9NYA2 Q0QVW8
Accessions	AAC63331 AAD14942 AAY22177 ACW84342 BAA76937 BAA76938 BAA76939 CAY55955 EAW80120 P13501 AA443491 AA486131 AF043341 AAC03541 AF266753 AAF73070 AK312212 BAG35145 AW769950 BC008600 AAH08600 BG272739 CB111656 CD695497 CR980938 DQ230537 ABB69929 DQ891490 ABM82416 DQ894681 ABM85607 GD136908 HY265548 M21121 AAA36725 NM_001278736 NP_001265665 NM_002985 NP_002976
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobiliz
Subcellular Location	Secreted.
Tissue Specificity	T-cell and macrophage specific.
Top Pathways	TNF signaling pathway, Cytokine-cytokine receptor interaction, Herpes simplex infection, Influenza A, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RANTES (CCL5) Human SimpleStep ELISA™ Kit - ab174446 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 2 pg/ml Range 3.125 pg/ml - 1000 pg/ml

RANTES Human ELISA Kit - ab100633 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 3 pg/ml Range 2.74 pg/ml - 2000 pg/ml

Human CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F5172 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.819-80 pg/ml

Rat CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F5505 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 5.9 pg/ml Range 0.819-80 pg/ml

Guinea pig CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F5961 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.819-80 pg/ml

Pig CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F5962 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 1.15 ng/ml Range 0.819-80 pg/ml

Human CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F2537 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 3 pg/ml Range 0.819-80 pg/ml

Mouse CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F2538 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 1 pg/ml Range 0.819-80 pg/ml

Rat CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F2539 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 1 pg/ml Range 0.819-80 pg/ml

Mouse CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F4531 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 0.819-80 pg/ml

Mouse CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F286 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.819 pg/ml Range 0.819-80 pg/ml

Human CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F595 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.819-80 pg/ml

Feline/Cat CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F22 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.819 pg/ml Range 0.819-80 pg/ml

Human CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F178 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.743 pg/ml Range 0.819-80 pg/ml

Rat CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F630 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.819-80 pg/ml

Mouse CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F622 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.819-80 pg/ml

Human CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F10170 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 2.307 pg/ml Range 0.819-80 pg/ml

Dog CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F10192 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.081 ng/ml Range 0.819-80 pg/ml

Guinea pig CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F10193 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.081 ng/ml Range 0.819-80 pg/ml

Mouse CCL5 / RANTES ELISA Kit (Sandwich ELISA) - LS-F11064 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 39 Range 0.819-80 pg/ml

Human RANTES / CCL5 ELISA Kit - RAB0076 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

Human CCL5/RANTES Biotinylated Fluorokine Flow Cytometry Kit - NFRN0 from R&D Systems Prices $405.00 Sizes 1 kit

Human CCL5/RANTES Luminex Performance Assay - LUH278 from R&D Systems

Human CCL5/RANTES Magnetic Luminex Performance Assay - LUHM278 from R&D Systems

Human CCL5/RANTES Quantikine ELISA Kit - DRN00B from R&D Systems Category ELISA Kit Prices $479.00, $2,290.00, $15,560.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 6.6 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma, Urine)

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