| Gene Symbol |
FCRL5
|
| Entrez Gene |
83416
|
| Alt Symbol |
BXMAS1, CD307, CD307e, FCRH5, IRTA2, PRO820
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fc receptor-like 5
|
| Other Description |
Fc receptor-like protein 5|fc receptor homolog 5|fcR-like protein 5|immune receptor translocation-associated protein 2|immunoglobulin superfamily receptor translocation associated 2 (IRTA2)
|
| Swissprots |
Q495Q2 B7WP94 Q96RD9 Q495Q4 B7WNT9 Q6UY46 Q5VYK9 A0N0M2
|
| Accessions |
ABK41913 EAW52884 EAW52885 EAW52886 Q96RD9 AF343662 AAK31325 AF343663 AAK31326 AF343664 AAK31327 AF343665 AAK31328 AF369794 AAK50059 AF397453 AAK93971 AK090423 BAC03404 AK090475 BAC03456 AK300010 BAH13192 AK301356 BAG62901 AL832301 AL834187 CAH56486 AY358085 AAQ88452 BC101066 AAI01067 BC101067 AAI01068 BC101068 BC101069 AAI01070 BE676280 XM_011510030 XP_011508332 XM_011510031 XP_011508333 XM_011510032 XP_011508334 XM_011510033 XP_011508335 NM_001195388 NP_001182317 NM_031281 NP_112571
|
| Function |
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. {ECO:0000269|PubMed:11453668}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
|
| Tissue Specificity |
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level). {ECO:0000269|PubMed:11290337, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:16849395}.
|