Gene Symbol | DYX1C1 |
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Entrez Gene | 161582 |
Alt Symbol | CILD25, DNAAF4, DYX1, DYXC1, EKN1, RD |
Species | Human |
Gene Type | protein-coding |
Description | dyslexia susceptibility 1 candidate 1 |
Other Description | dynein, axonemal, assembly factor 4|dyslexia susceptibility 1 candidate gene 1 protein |
Swissprots | Q8N1S6 Q8WXU2 Q6P5Y9 |
Accessions | EAW77490 EAW77491 Q8WXU2 AF337549 AAL73230 AK095201 BAC04498 AK302316 BAG63654 BC017392 BC062564 AAH62564 BM971229 NM_001033559 NP_001028731 NM_001033560 NP_001028732 NM_130810 NP_570722 |
Function | Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility. {ECO:0000269|PubMed:19423554, ECO:0000269|PubMed:23872636}. |
Subcellular Location | Nucleus. Cytoplasm. |
Tissue Specificity | Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells. {ECO:0000269|PubMed:12954984}. |
DYX1C1 CRISPR/Cas9 KO Plasmid (h) - sc-414830 from Santa Cruz Biotechnology
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DYX1C1 HDR Plasmid (h) - sc-414830-HDR from Santa Cruz Biotechnology
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DYX1C1 Double Nickase Plasmid (h) - sc-414830-NIC from Santa Cruz Biotechnology
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DYX1C1 Double Nickase Plasmid (h2) - sc-414830-NIC-2 from Santa Cruz Biotechnology
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DYX1C1 CRISPR Activation Plasmid (h) - sc-414830-ACT from Santa Cruz Biotechnology
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DYX1C1 CRISPR Activation Plasmid (h2) - sc-414830-ACT-2 from Santa Cruz Biotechnology
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DYX1C1 Lentiviral Activation Particles (h) - sc-414830-LAC from Santa Cruz Biotechnology
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DYX1C1 Lentiviral Activation Particles (h2) - sc-414830-LAC-2 from Santa Cruz Biotechnology
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DYX1C1 siRNA (h) - sc-60562 from Santa Cruz Biotechnology
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DYX1C1 shRNA Plasmid (h) - sc-60562-SH from Santa Cruz Biotechnology
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DYX1C1 shRNA (h) Lentiviral Particles - sc-60562-V from Santa Cruz Biotechnology
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DYX1C1 RNAi - H00161582-R03 from Novus Biologicals
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MISSION® esiRNA - EHU117501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7601 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03729 from Sigma-Aldrich
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DYX1C1 siRNA (Human) - CRJ5930 from Cohesion Biosciences
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DYX1C1 RNAi - H00161582-R02 from Novus Biologicals
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DYX1C1 RNAi - H00161582-R01 from Novus Biologicals
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DYX1C1 - MBS8206595 from MyBioSource
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shRNA set against Human DYX1 (NM_130810.3) - SHH282357 from Creative biogene
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shRNA set against Human DYX1C1(NM_001033560.1) - SHH021215 from Creative biogene
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Human DYX1C1 siRNA - orb276431 from Biorbyt
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DYX1C1 shRNA Plasmid (Human) - CHJ5930 from Cohesion Biosciences
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DYX1C1 miRNA 3'UTR clone - MiUTR1H-03072 from Creative biogene
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