Gene Symbol | MFNG |
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Entrez Gene | 4242 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
Other Description | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase|beta-1,3-N-acetylglucosaminyltransferase manic fringe |
Swissprots | Q504S9 O00587 O43730 B4DLT6 |
Accessions | CAB07511 CAP58790 CAP58791 CAP58792 CAP58793 EAW60161 EAW60162 O00587 AI363008 AK292123 BAF84812 AK297149 BAG59648 AK297833 BAG60167 AK316555 BAG65633 BC094814 AAH94814 BM457814 CR456518 CAG30404 CU013118 CAK54549 CU013406 CAK54848 DA815501 U94352 AAC51358 NM_001166343 NP_001159815 NM_002405 NP_002396 NR_029413 |
Function | Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. {ECO:0000269|PubMed:10935626}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Other types of O-glycan biosynthesis, Notch signaling pathway |
Manic Fringe CRISPR/Cas9 KO Plasmid (h) - sc-407042 from Santa Cruz Biotechnology
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Manic Fringe HDR Plasmid (h) - sc-407042-HDR from Santa Cruz Biotechnology
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Manic Fringe Double Nickase Plasmid (h) - sc-407042-NIC from Santa Cruz Biotechnology
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Manic Fringe Double Nickase Plasmid (h2) - sc-407042-NIC-2 from Santa Cruz Biotechnology
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Manic Fringe CRISPR Activation Plasmid (h) - sc-407042-ACT from Santa Cruz Biotechnology
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Manic Fringe CRISPR Activation Plasmid (h2) - sc-407042-ACT-2 from Santa Cruz Biotechnology
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Manic Fringe Lentiviral Activation Particles (h) - sc-407042-LAC from Santa Cruz Biotechnology
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Manic Fringe Lentiviral Activation Particles (h2) - sc-407042-LAC-2 from Santa Cruz Biotechnology
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Manic Fringe siRNA (h) - sc-39492 from Santa Cruz Biotechnology
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Manic Fringe shRNA Plasmid (h) - sc-39492-SH from Santa Cruz Biotechnology
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Manic Fringe shRNA (h) Lentiviral Particles - sc-39492-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13256 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13256 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07329 from Sigma-Aldrich
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MFNG siRNA (Human) - CRH2884 from Cohesion Biosciences
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MFNG RNAi - H00004242-R01 from Novus Biologicals
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shRNA set against Human Mfng (NM_002405.3) - SHH341127 from Creative biogene
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MFNG shRNA Plasmid (Human) - CHH2884 from Cohesion Biosciences
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MFNG miRNA 3'UTR clone - MiUTR3H-05094 from Creative biogene
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