| Gene Symbol |
RAB3GAP2
|
| Entrez Gene |
25782
|
| Alt Symbol |
RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB3 GTPase activating protein subunit 2 (non-catalytic)
|
| Other Description |
RGAP-iso|rab3 GTPase-activating protein 150 kDa subunit|rab3 GTPase-activating protein non-catalytic subunit|rab3-GAP p150|rab3-GAP regulatory subunit
|
| Swissprots |
Q9HAB0 Q9UFJ7 O75872 A6H8V0 Q9H2M9 Q9UQ15
|
| Accessions |
EAW93304 Q9H2M9 AB020646 BAA74862 AF004828 AAC35881 AF255648 AAG44636 AK021928 BAB13939 AK027485 BAG51330 AK291234 BAF83923 AL117631 CAB56022 BC036513 BC098383 BC131573 BC146760 AAI46761 BX483077 DA379077 N93244 NM_012414 NP_036546
|
| Function |
Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. {ECO:0000269|PubMed:9733780}.
|
| Subcellular Location |
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:9733780}.
|
![Western Blot: RAB3GAP2 Overexpression Lysate (Adult Normal) [NBP2-07447] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB3GAP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9130_RAB3GAP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07447-img0001.jpg)