Gene Symbol | RAB3GAP2 |
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Entrez Gene | 25782 |
Alt Symbol | RAB3-GAP150, RAB3GAP150, SPG69, WARBM2, p150 |
Species | Human |
Gene Type | protein-coding |
Description | RAB3 GTPase activating protein subunit 2 (non-catalytic) |
Other Description | RGAP-iso|rab3 GTPase-activating protein 150 kDa subunit|rab3 GTPase-activating protein non-catalytic subunit|rab3-GAP p150|rab3-GAP regulatory subunit |
Swissprots | Q9HAB0 Q9UFJ7 O75872 A6H8V0 Q9H2M9 Q9UQ15 |
Accessions | EAW93304 Q9H2M9 AB020646 BAA74862 AF004828 AAC35881 AF255648 AAG44636 AK021928 BAB13939 AK027485 BAG51330 AK291234 BAF83923 AL117631 CAB56022 BC036513 BC098383 BC131573 BC146760 AAI46761 BX483077 DA379077 N93244 NM_012414 NP_036546 |
Function | Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. {ECO:0000269|PubMed:9733780}. |
Subcellular Location | Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9733780}. |
Rab 3 GAP p150 CRISPR/Cas9 KO Plasmid (h) - sc-408016 from Santa Cruz Biotechnology
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Rab 3 GAP p150 HDR Plasmid (h) - sc-408016-HDR from Santa Cruz Biotechnology
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Rab 3 GAP p150 Double Nickase Plasmid (h) - sc-408016-NIC from Santa Cruz Biotechnology
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Rab 3 GAP p150 Double Nickase Plasmid (h2) - sc-408016-NIC-2 from Santa Cruz Biotechnology
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Rab 3 GAP p150 CRISPR Activation Plasmid (h) - sc-408016-ACT from Santa Cruz Biotechnology
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Rab 3 GAP p150 CRISPR Activation Plasmid (h2) - sc-408016-ACT-2 from Santa Cruz Biotechnology
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Rab 3 GAP p150 Lentiviral Activation Particles (h) - sc-408016-LAC from Santa Cruz Biotechnology
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Rab 3 GAP p150 Lentiviral Activation Particles (h2) - sc-408016-LAC-2 from Santa Cruz Biotechnology
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Rab 3 GAP p150 siRNA (h) - sc-78762 from Santa Cruz Biotechnology
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Rab 3 GAP p150 shRNA Plasmid (h) - sc-78762-SH from Santa Cruz Biotechnology
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Rab 3 GAP p150 shRNA (h) Lentiviral Particles - sc-78762-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17847 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17847 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07399 from Sigma-Aldrich
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RAB3GAP2 siRNA (Human) - CRH8492 from Cohesion Biosciences
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RAB3GAP2 - MBS8233615 from MyBioSource
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shRNA set against Human Rab3gap2 (NM_012414.3) - SHH388356 from Creative biogene
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Human RAB3GAP2 siRNA - orb268994 from Biorbyt
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RAB3GAP2 shRNA Plasmid (Human) - CHH8492 from Cohesion Biosciences
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RAB3GAP2 miRNA 3'UTR clone - MiUTR4H-TG12265 from Creative biogene
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