| Gene Symbol |
Cyp8b1
|
| Entrez Gene |
13124
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 8, subfamily b, polypeptide 1
|
| Other Description |
7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, 8b1, sterol 12 alpha-hydrolase|sterol 12-alpha-hydrolase|sterol 12-alpha-hydroxylase
|
| Swissprots |
Q9R217 O88962
|
| Accessions |
AAD19876 EDL09122 O88962 AF090317 AAC63036 BC010973 AAH10973 BC010974 AAH10974 BC049969 AAH49969 NM_010012 NP_034142
|
| Function |
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in liver.
|
| Top Pathways |
Primary bile acid biosynthesis, PPAR signaling pathway
|