Gene Symbol | Cyp8b1 |
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Entrez Gene | 13124 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | cytochrome P450, family 8, subfamily b, polypeptide 1 |
Other Description | 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, 8b1, sterol 12 alpha-hydrolase|sterol 12-alpha-hydrolase|sterol 12-alpha-hydroxylase |
Swissprots | Q9R217 O88962 |
Accessions | AAD19876 EDL09122 O88962 AF090317 AAC63036 BC010973 AAH10973 BC010974 AAH10974 BC049969 AAH49969 NM_010012 NP_034142 |
Function | Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
Tissue Specificity | Expressed in liver. |
Top Pathways | Primary bile acid biosynthesis, PPAR signaling pathway |
CYP8B1 CRISPR/Cas9 KO Plasmid (m) - sc-419934 from Santa Cruz Biotechnology
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CYP8B1 HDR Plasmid (m) - sc-419934-HDR from Santa Cruz Biotechnology
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CYP8B1 Double Nickase Plasmid (m) - sc-419934-NIC from Santa Cruz Biotechnology
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CYP8B1 Double Nickase Plasmid (m2) - sc-419934-NIC-2 from Santa Cruz Biotechnology
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CYP8B1 CRISPR Activation Plasmid (m) - sc-419934-ACT from Santa Cruz Biotechnology
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CYP8B1 CRISPR Activation Plasmid (m2) - sc-419934-ACT-2 from Santa Cruz Biotechnology
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CYP8B1 Lentiviral Activation Particles (m) - sc-419934-LAC from Santa Cruz Biotechnology
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CYP8B1 Lentiviral Activation Particles (m2) - sc-419934-LAC-2 from Santa Cruz Biotechnology
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CYP8B1 siRNA (m) - sc-41495 from Santa Cruz Biotechnology
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CYP8B1 shRNA Plasmid (m) - sc-41495-SH from Santa Cruz Biotechnology
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CYP8B1 shRNA (m) Lentiviral Particles - sc-41495-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29585 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29585 from Sigma-Aldrich
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CYP8B1 siRNA (Mouse) - CRM0961 from Cohesion Biosciences
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CYP8B1 - MBS8206808 from MyBioSource
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shRNA set against Mouse CYP8B1 (NM_010012.3) - SHH273813 from Creative biogene
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Mouse CYP8B1 siRNA - orb280437 from Biorbyt
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CYP8B1 shRNA Plasmid (Mouse) - CHM0961 from Cohesion Biosciences
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