Cyp8b1

Gene Symbol Cyp8b1
Entrez Gene 13124
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description cytochrome P450, family 8, subfamily b, polypeptide 1
Other Description 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, 8b1, sterol 12 alpha-hydrolase|sterol 12-alpha-hydrolase|sterol 12-alpha-hydroxylase
Swissprots Q9R217 O88962
Accessions AAD19876 EDL09122 O88962 AF090317 AAC63036 BC010973 AAH10973 BC010974 AAH10974 BC049969 AAH49969 NM_010012 NP_034142
Function Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity Expressed in liver.
Top Pathways Primary bile acid biosynthesis, PPAR signaling pathway

CYP8B1 CRISPR/Cas9 KO Plasmid (m) - sc-419934 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 HDR Plasmid (m) - sc-419934-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 Double Nickase Plasmid (m) - sc-419934-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 Double Nickase Plasmid (m2) - sc-419934-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 CRISPR Activation Plasmid (m) - sc-419934-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 CRISPR Activation Plasmid (m2) - sc-419934-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 Lentiviral Activation Particles (m) - sc-419934-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 Lentiviral Activation Particles (m2) - sc-419934-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CYP8B1 siRNA (m) - sc-41495 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CYP8B1 shRNA Plasmid (m) - sc-41495-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CYP8B1 shRNA (m) Lentiviral Particles - sc-41495-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN29585 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29585 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CYP8B1 siRNA (Mouse) - CRM0961 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CYP8B1 - MBS8206808 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse CYP8B1 (NM_010012.3) - SHH273813 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse CYP8B1 siRNA - orb280437 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CYP8B1 shRNA Plasmid (Mouse) - CHM0961 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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