| Gene Symbol |
PLSCR2
|
| Entrez Gene |
57047
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipid scramblase 2
|
| Other Description |
PL scramblase 2|ca(2+)-dependent phospholipid scramblase 2
|
| Swissprots |
J3KR76 Q6NSW9 Q9NRY7 B4DXC3 Q7Z4L7 Q0VAQ1
|
| Accessions |
CBH19416 CBH30688 EAW78931 EAW78932 Q9NRY7 AA813518 AF159441 AAF91082 AK301909 BAG63335 BC055415 AAH55415 BC069785 AAH69785 BC120969 AAI20970 BC141969 AAI41970 BU852276 XM_011513012 XP_011511314 XM_011513013 XP_011511315 XM_011513014 XP_011511316 XM_011513015 XP_011511317 XM_011513016 XP_011511318 XM_011513017 XP_011511319 XM_011513018 XP_011511320 XM_011513019 XP_011511321 XM_011513020 XP_011511322 XM_011513021 XP_011511323 XM_011513022 XP_011511324 XM_011513023 XP_011511325 XM_011513024 XP_011511326 XM_011513025 XP_011511327 XM_011513026 XP_011511328 XM_011513027 XP_011511329 XM_011513028 XP_011511330 XM_011513029 XP_011511331 XM_011513030 XP_011511332 NM_001199978 NP_001186907 NM_001199979 NP_001186908 NM_020359 NP_065092
|
| Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expression of isoform 1 seems restricted to testis. {ECO:0000269|PubMed:10930526}.
|
![Western Blot: PLSCR2 Overexpression Lysate (Adult Normal) [NBP2-06661] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PLSCR2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1685_PLSCR2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06661-img0001.jpg)