ITGA6

Gene Symbol ITGA6
Entrez Gene 3655
Alt Symbol CD49f, ITGA6B, VLA-6
Species Human
Gene Type protein-coding
Description integrin, alpha 6
Other Description CD49 antigen-like family member F|integrin alpha-6|integrin alpha6B
Swissprots Q0MRC7 Q14646 Q53RX7 C4AM96 P23229 G5E9H1 B4DG69 Q86VL6 Q9UCT1 Q08443 Q9UN03 Q59HB7 B2RMU9 Q16508 B4DKB8
Accessions AAB24829 AAD48469 AAX93133 CCF76946 CCF76947 EAX11175 EAX11176 EAX11177 P23229 AB208842 BAD92079 AF401206 AK294436 BAG57680 AK296496 BAG59130 AK307777 AK311695 BC007002 BC050585 AAH50585 BC136455 AAI36456 BC136456 AAI36457 BX537483 DA760250 DQ858220 ABH11650 EF491782 EF491790 EF491812 S66196 AAB20354 S66213 AAB20355 X53586 CAA37655 X59512 CAA42099 XM_006712510 XP_006712573 XM_006712511 XP_006712574 NM_000210 NP_000201 NM_001079818 NP_001073286
Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. {ECO:0000269|PubMed:17303120}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000269|PubMed:22314500}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}.
Tissue Specificity Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). {ECO:0000269|PubMed:7681434}.
Top Pathways PI3K-Akt signaling pathway, Focal adhesion, Toxoplasmosis, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Integrin α6 Antibody - 3750 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines and tissues using Integrin α6 Antibody.

Integrin α6 (F-6) - sc-374057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α6 (F-6): sc-374057. Western blot analysis of Integrin α6 expression in human platelet extract.

Integrin α6 (H-87) - sc-10730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin α6 (H-87): sc-10730. Western blot analysis of Integrin α6 expression in F9 whole cell lysate.

Integrin α6 (N-19) - sc-6597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin α6 (N-19): sc-6597. Western blot analysis of Integrin α6 expression in human platelet extract.

Integrin α6 (BQ16) - sc-13542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α6 (BQ16): sc-13542. Western blot analysis of Integrin α6 expression in Hep G2 whole cell lysate.

Integrin α6 (GOH3) - sc-19622 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
Integrin α6 (GOH3) FITC: sc-19622 FITC. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal rat IgG<sub>2a</sub>: sc-2831.

Integrin α6 (C-18) - sc-6596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin α6 (C-18): sc-6596. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing membrane localization.

Integrin α6 (4F10) - sc-53356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α6 (4F10): sc-53356. Western blot analysis of Integrin α6 expression in Hep G2 whole cell lysate.

Integrin α6 (541A11) - sc-47772 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α6 (541A11): sc-47772. Western blot analysis of Integrin α6 expression in NTERA-2 cl.D1 (A), T84 (B) and DU 145 (C) whole cell lysates.

Integrin α6 (450-30A) - sc-59842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α6 (NKI-GOH3) - sc-80554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal

Integrin α6 (3H1512) - sc-71423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α6 (2Q959) - sc-71427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin α6 (1.BB.460) - sc-71426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αVIa (1A10) - sc-59970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Integrin αVIb (6B4) - sc-59971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Integrin alpha 6 antibody - ab75737 from Abcam

Prices $390.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Integrin alpha 6 antibody (ab75737) at 1/50 dilution + 293 cell lysate at 35 µgSecondaryHRP goat anti-rabbit (H+L) at 1/5000 dilution

Anti-Integrin alpha 6 antibody - ab112181 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Integrin alpha 6 antibody (ab112181) at 1 µg/ml + Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Integrin alpha 6 antibody - ab169299 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Integrin alpha 6 antibody (ab169299) at 1 µg/ml + A431 cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-Integrin alpha 6 antibody - ab133386 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin embedded human stomach labelling Integrin alpha 6 with ab133386 at 1 µg/ml. Followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Integrin alpha 6 antibody - ab134579 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Integrin alpha 6 by Western Blot of Immunprecipitate. Immunoprecipitation of HeLa whole cell lysate using ab134579 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane) followed by detection of Integrin alpha 6 with an antibody to a downstream epitope at 1µg/ml. The lysate in lane 2 is precipitated with an IgG control antibody. Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-Integrin alpha 6 antibody [450-30A] (FITC) - ab30496 from Abcam

Prices $189.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 450-30A
Flow cytometric analysis of peripheral blood lymphocytes with 10µl for 106 cells of anti human Integrin alpha 6 FITC conjugated (ab30496).

Anti-Integrin alpha 6 antibody [450-30A] (Phycoerythrin) - ab30497 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 450-30A
Flow cytometric analysis of peripheral blood monocytes with 10µl for 106 cells of anti human Integrin alpha 6 Phycoerythrin conjugated (ab30497).

Anti-Integrin alpha 6 antibody [EPR18124] - ab181551 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR18124
Immunohistochemical analysis of paraffin-embedded Human breast tissue labeling Intergrin alpha 6 with ab181551 at 1/500 followed by Goat Anti-Rabbit IgG (HRP) at 1/500.  Membrane and cytoplasm staining on epithelial cells of Human breast tissue is observed.Counter stained with Hematoxylin.Negative control: Used PBS instead of primary antibody followed by Goat Anti-Rabbit IgG (HRP) at 1/500.

Anti-Integrin alpha 6 antibody [EPR5578] - ab124924 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5578
All lanes : Anti-Integrin alpha 6 antibody [EPR5578] (ab124924) at 1/1000 dilutionLane 1 : JAR cell lysates Lane 2 : HT1376 cell lysates Lane 3 : Human platelet lysates Lysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution
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