ITGA6

Gene Symbol	ITGA6
Entrez Gene	3655
Alt Symbol	CD49f, ITGA6B, VLA-6
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 6
Other Description	CD49 antigen-like family member F|integrin alpha-6|integrin alpha6B
Swissprots	Q0MRC7 Q14646 Q53RX7 C4AM96 P23229 G5E9H1 B4DG69 Q86VL6 Q9UCT1 Q08443 Q9UN03 Q59HB7 B2RMU9 Q16508 B4DKB8
Accessions	AAB24829 AAD48469 AAX93133 CCF76946 CCF76947 EAX11175 EAX11176 EAX11177 P23229 AB208842 BAD92079 AF401206 AK294436 BAG57680 AK296496 BAG59130 AK307777 AK311695 BC007002 BC050585 AAH50585 BC136455 AAI36456 BC136456 AAI36457 BX537483 DA760250 DQ858220 ABH11650 EF491782 EF491790 EF491812 S66196 AAB20354 S66213 AAB20355 X53586 CAA37655 X59512 CAA42099 XM_006712510 XP_006712573 XM_006712511 XP_006712574 NM_000210 NP_000201 NM_001079818 NP_001073286
Function	Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. {ECO:0000269|PubMed:17303120}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22314500}; Single-pass type I membrane protein {ECO:0000269|PubMed:22314500}. Cell membrane {ECO:0000269|PubMed:22314500}; Lipid-anchor {ECO:0000269|PubMed:22314500}.
Tissue Specificity	Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). {ECO:0000269|PubMed:7681434}.
Top Pathways	PI3K-Akt signaling pathway, Focal adhesion, Toxoplasmosis, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ITGA6 cDNA clone(NM_001079818.1) - CDFH009430 from Creative Biomart Species Human Accession NM_001079818.1

Human ITGA6 ORF clone(NM_000210.2) - CDCL184976 from Creative Biomart Species Human Accession NM_000210.2

Human ITGA6 ORF Clone(NM_001079818.1) - CDCR345437 from Creative Biomart Species Human Accession NM_001079818.1

Human ITGA6 ORF Clone(NM_001079818.1) - CDCR345438 from Creative Biomart Species Human Accession NM_001079818.1

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone in cloning vector - HG13016-M from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13016-ACG from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13016-CY from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13016-NF from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13016-NY from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13016-NM from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13016-CF from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG13016-NH from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13016-CM from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13016-ACR from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid - HG13016-UT from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG13016-CH from Sino Biological Species Human

Human Integrin alpha 6/ITGA6 transcript variant 2 Gene ORF cDNA clone expression plasmid - HG13016-M-N from Sino Biological Species Human

Human ITGA6 ORF clone(NM_000210.2) - CDCL184976 from Creative biogene Species Human

Mouse ITGA6 ORF clone (NM_001079818.1) - CDCL121895 from Creative biogene Species Human

Human ITGA6 cDNA Clone(NM_001079818.1) - CDFH009430 from Creative biogene Species Human

Human Integrin alpha 6/CD49f (NP_001073286) VersaClone cDNA - RDC0884 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

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