RUNX2

Gene Symbol RUNX2
Entrez Gene 860
Alt Symbol AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
Species Human
Gene Type protein-coding
Description runt-related transcription factor 2
Other Description PEA2-alpha A|PEBP2-alpha A|SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|acute myeloid leukemia 3 protein|core-binding factor, runt domain, alpha subunit 1|oncogene AML-3|osteoblast-specific transcription factor 2|polyomavirus enhancer-binding protein 2 alpha A subunit
Swissprots O14615 Q13950 O95181 O14614
Accessions AAB65158 AAB65159 AAC77441 AAM21761 AEC33225 AGW99946 BAA88712 CCQ43044 EAX04277 EAX04278 EAX04279 EAX04280 EAX04281 EAX04282 Q13950 AF053952 AAC78624 AF087960 AL353944 AW469546 BC108919 AAI08920 BC108920 AAI08921 BC160022 AAI60022 BX108677 CD001961 CN431726 DR005078 L40992 AAA89072 XM_006715232 XP_006715295 XM_011514960 XP_011513262 XM_011514961 XP_011513263 XM_011514962 XP_011513264 XM_011514963 XP_011513265 XM_011514964 XP_011513266 XM_011514965 XP_011513267 XM_011514966 XP_011513268 XM_011514967 XP_011513269 XM_011514968 XP_011513270 XR_926323 NM_001015051 NP_001015051 NM_001024630 NP_001019801 NM_001278478 NP_001265407 NR_103532 NR_103533 NM_004348
Function Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546}.
Subcellular Location Nucleus.
Tissue Specificity Specifically expressed in osteoblasts.
Top Pathways Transcriptional misregulation in cancer

SimpleChIP ® Human RUNX2 Promoter Primers - 12376 from Cell Signaling Technology

Category ChIP Kit
Prices $102.00
Sizes 500 µl (250 PCR reactions)
SimpleChIP ® Human RUNX2 Promoter Primers were tested on DNA isolated from cross-linked cells using the SimpleChIP ® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. Real-time PCR was performed in duplicate on a serial dilution of 2% total input DNA (20 ng, 4 ng, 0.8 ng, and 0.16 ng) using a real-time PCR detection system and SYBR ® Green reaction mix. The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 65°C anneal/extension for 60 sec).

Human CBFA1 / RUNX2 ELISA Kit (Sandwich ELISA) - LS-F4390 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

Mouse CBFA1 / RUNX2 ELISA Kit (Sandwich ELISA) - LS-F7649 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.116 ng/ml
Range 0.156-10 ng/ml

Human CBFA1 / RUNX2 ELISA Kit (Sandwich ELISA) - LS-F12520 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312
Range 0.156-10 ng/ml

Core Binding Factor alpha1 CBFA1/RUNX2, Human, ELISA Kit - CSB-E12935h from ARP American Research Products

Category ELISA Kit
Prices $550.00, $790.00, $791.00, $794.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Runt Related Transcription Factor 2 (RUNX2), Human, ELISA Kit - SEB011Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 0.053ng/mL
Range 0.156-10ng/mL

Runt-related transcription factor 2, RUNX2, Human, ELISA Kit - E9029h from ARP American Research Products

Category ELISA Kit
Prices $660.00
Sizes 96 t
Range 0.312-20 ng/mL

Runt-Related Transcription Factor 2, RUNX2, Human, ELISA Kit - E-EL-H0925 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Runt Related Transcription Factor 2, RUNX2, Mouse, ELISA Kit - E-EL-M1030 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Runt Related Transcription Factor 2, RUNX2, Rat, ELISA Kit - E-EL-R0866 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Runt-Related Transcription Factor 2, RUNX2, Rabbit, ELISA Kit - E-EL-RB1541 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Runt-Related Transcription Factor 2, RUNX2, Chicken, ELISA Kit - E-EL-Ch0227 from ARP American Research Products

Category ELISA Kit
Prices $445.50
Sizes 96 t

Runt-Related Transcription Factor 2, RUNX2, Porcine, ELISA Kit - E-EL-P1173 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Runt-Related Transcription Factor 2, RUNX2, Guinea Pig, ELISA Kit - E-EL-GP0173 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Runt-Related Transcription Factor 2, RUNX2, Monkey, ELISA Kit - E-EL-MK1068 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human RUNX2 ELISA Kit - HR0105 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine RUNX2 ELISA Kit - AR0105 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Human RUNX2(Runt-Related Transcription Factor 2) ELISA Kit - E-EL-H0925 from Elabscience

Category ELISA Kit
Sensitivity 0.19 ng/mL
Range 0.31—20 ng/mL

Human RUNX2 (Runt-Related Transcription Factor 2) CLIA Kit - E-CL-H0630 from Elabscience

Category CLIA Kit
Sensitivity 37.50 pg/mL
Range Average Recovery (%)

Runt Related Transcription Factor 2, ELISA Kit - MBS740376 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Runt Related Transcription Factor 2, ELISA Kit - MBS738272 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Runt-related transcription factor 2, ELISA Kit - MBS281009 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.625 ng/mL - 40 ng/mL

runt-related transcription factor 2, ELISA Kit - MBS700348 from MyBioSource

Category ELISA Kit
Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <7.8 pg/ml
Range 31.25 pg/ml-2000 pg/ml

RUNX2, ELISA Kit - MBS2505991 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/mL
Range 0.625-40ng/mL
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