RUNX2

Gene Symbol	RUNX2
Entrez Gene	860
Alt Symbol	AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
Species	Human
Gene Type	protein-coding
Description	runt-related transcription factor 2
Other Description	PEA2-alpha A|PEBP2-alpha A|SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|acute myeloid leukemia 3 protein|core-binding factor, runt domain, alpha subunit 1|oncogene AML-3|osteoblast-specific transcription factor 2|polyomavirus enhancer-binding protein 2 alpha A subunit
Swissprots	O14615 Q13950 O95181 O14614
Accessions	AAB65158 AAB65159 AAC77441 AAM21761 AEC33225 AGW99946 BAA88712 CCQ43044 EAX04277 EAX04278 EAX04279 EAX04280 EAX04281 EAX04282 Q13950 AF053952 AAC78624 AF087960 AL353944 AW469546 BC108919 AAI08920 BC108920 AAI08921 BC160022 AAI60022 BX108677 CD001961 CN431726 DR005078 L40992 AAA89072 XM_006715232 XP_006715295 XM_011514960 XP_011513262 XM_011514961 XP_011513263 XM_011514962 XP_011513264 XM_011514963 XP_011513265 XM_011514964 XP_011513266 XM_011514965 XP_011513267 XM_011514966 XP_011513268 XM_011514967 XP_011513269 XM_011514968 XP_011513270 XR_926323 NM_001015051 NP_001015051 NM_001024630 NP_001019801 NM_001278478 NP_001265407 NR_103532 NR_103533 NM_004348
Function	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546}.
Subcellular Location	Nucleus.
Tissue Specificity	Specifically expressed in osteoblasts.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RUNX2 peptide - ab26346 from Abcam Category Peptide

Human RUNX2 protein fragment - ab112258 from Abcam Category Protein Source Wheat germ Species Human

Human RUNX2 protein fragment - ab112259 from Abcam Category Protein Source Wheat germ Species Human

CBFA1 / RUNX2 Antibody Blocking Peptide - LS-E10810 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBFA1 / RUNX2 Antibody Blocking Peptide - LS-E7419 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBFA1 / RUNX2 Antibody Blocking Peptide - LS-E13819 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBFA1 / RUNX2 Antibody Blocking Peptide - LS-E13820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CBFA1 / RUNX2 Antibody Blocking Peptide - LS-E9232 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RUNX2/CBFA1 Protein - H00000860-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RUNX2/CBFA1 Protein - H00000860-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RUNX2/CBFA1 Peptide - P1688 from Novus Biologicals Category Peptide Species Human

Phospho-RUNX2S465-Antibody-Blocking-peptide - BP3559a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

RUNX2-Antibody-S533-Blocking-peptide - BP7735d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RUNX2 Blocking Peptide - 33R-2188 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human RUNX2 Protein - abx068940 from Abbexa Category Protein Source E.coli Species Human

RUNX2 Blocking Peptide - abx062356 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

RUNX2 - H00000860-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RUNX2 - H00000860-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RUNX2 - H00000860-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

RUNX2 - H00000860-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RUNX2 - H00000860-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Runt Related Transcription Factor 2 (RUNX2), Human - 20-7381 from ARP American Research Products Category Protein Prices $535.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human RUNX2 - RUNX2-28321TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human RUNX2 - RUNX2-30473TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Runt Related Transcription Factor 2 (RUNX2) - RPB011Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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