| Gene Symbol |
H1FOO
|
| Entrez Gene |
132243
|
| Alt Symbol |
H1.8, osH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
H1 histone family, member O, oocyte-specific
|
| Other Description |
histone H1oo|oocyte-specific histone H1|oocyte-specific linker histone H1
|
| Swissprots |
Q86WT7 Q8IZA3
|
| Accessions |
EAW79242 EAW79243 Q8IZA3 AY158091 AAN46899 BC047943 AAH47943 BM564157 XM_005247123 XP_005247180 NM_001308262 NP_001295191 NM_153833 NP_722575
|
| Function |
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
|
| Tissue Specificity |
Oocyte-specific. {ECO:0000269|PubMed:12711322}.
|