Gene Symbol | CSPG4 |
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Entrez Gene | 1464 |
Alt Symbol | HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 |
Species | Human |
Gene Type | protein-coding |
Description | chondroitin sulfate proteoglycan 4 |
Other Description | chondroitin sulfate proteoglycan 4 (melanoma-associated)|chondroitin sulfate proteoglycan NG2|melanoma chondroitin sulfate proteoglycan|melanoma-associated chondroitin sulfate proteoglycan |
Swissprots | Q6UVK1 Q92675 D3DW77 |
Accessions | EAW99239 EAW99240 Q6UVK1 AY359468 AAQ62842 BC033194 BC128110 AAI28111 BC172270 AAI72270 BC172576 AAI72576 BP363063 BQ679485 CA428796 CA438367 CB044012 X96753 CAA65529 NM_001897 NP_001888 |
Function | Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activat |
Subcellular Location | Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250}. |
Tissue Specificity | Detected only in malignant melanoma cells. {ECO:0000269|PubMed:8790396}. |
Human NG2 peptide - ab96112 from Abcam
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Recombinant Human NG2/MCSP/CSPG4, CF - 2585-PG-050 from R&D Systems
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Human MCSP Protein - abx067979 from Abbexa
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Human MCSP Protein - abx067981 from Abbexa
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MCSP - H00004184-P01-02 from Acris Antibodies
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Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), Human - 20-7491 from ARP American Research Products
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Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP), Human - 20-7492 from ARP American Research Products
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu01 from Uscn Life Science Inc.
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu02 from Uscn Life Science Inc.
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Ra01 from Uscn Life Science Inc.
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Ra02 from Uscn Life Science Inc.
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Recombinant Glutathione Peroxidase 4 (GPX4) - RPC994Hu01 from Cloud-clone
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu01 from Cloud-clone
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Recombinant Melanoma Associated Chondroitin Sulfate Proteoglycan (MCSP) - RPB134Hu02 from Cloud-clone
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Recombinant Human Chondroitin sulfate proteoglycan 4(CSPG4) ,partial - CSB-YP006076HU CSB-EP006076HU CSB-BP006076HU CSB-MP006076HU from Cusabio
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Recombinant Human NG2/MCSP/CSPG4 Protein, CF - 2585-PG from R&D Systems
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NG2/MCSP Recombinant Protein Antigen - NBP1-94154PEP from Novus Biologicals
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NG2/MCSP Recombinant Protein Antigen - NBP1-89682PEP from Novus Biologicals
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CSPG4 Peptide, Human - M34GP03727H from Creative Peptides
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Chondroitin sulfate proteoglycan 4 (693-708) - ta-367 from Creative Peptides
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NG2 peptide - orb13014 from Biorbyt
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CSPG4 Recombinant Protein (OPCD05198) - OPCD05198 from Aviva Systems Biology
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CSPG4 Recombinant Protein (OPCD05199) - OPCD05199 from Aviva Systems Biology
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NG2/MCSP Recombinant Protein Antigen - NBP2-56911PEP from Novus Biologicals
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Chondroitin sulfate proteoglycan 4 (CSPG4), partial, Recombinant Protein - MBS1330587 from MyBioSource
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