| Gene Symbol |
CIDEA
|
| Entrez Gene |
1149
|
| Alt Symbol |
CIDE-A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell death-inducing DFFA-like effector a
|
| Other Description |
cell death activator CIDE-A
|
| Swissprots |
O60543 Q6UPR7 B0YIY7
|
| Accessions |
ACA05965 ACA05966 ADU05471 EAX01555 O60543 AA683375 AF041378 AAC34987 AK122762 BAG53714 AY364639 AAQ65241 BC031896 AAH31896 BQ718688 R73455 XM_011525602 XP_011523904 NM_001279 NP_001270 NR_036468
|
| Function |
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. {ECO:0000250, ECO:0000269|PubMed:19843876}.
|
| Subcellular Location |
Lipid droplet {ECO:0000269|PubMed:18509062}. Nucleus {ECO:0000250}. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). {ECO:0000250, ECO:0000269|PubMed:18509062}.
|
| Tissue Specificity |
Expressed in omental and subcutaneous adipose tissue (at protein level). {ECO:0000269|PubMed:18509062}.
|