| Gene Symbol |
MYOZ1
|
| Entrez Gene |
58529
|
| Alt Symbol |
CS-2, FATZ, MYOZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myozenin 1
|
| Other Description |
calsarcin-2|filamin-, actinin- and telethonin-binding protein|myozenin-1
|
| Swissprots |
Q9NP98 Q9H1I7
|
| Accessions |
AAG27296 EAW54506 Q9NP98 AA176752 AF240633 AAG24509 AJ278124 CAB92967 AK300683 BAG62366 AK308200 AL359210 CAB94568 AY013297 AAG38940 BC025753 AAH25753 DQ891549 ABM82475 DQ894737 ABM85663 NM_021245 NP_067068
|
| Function |
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
|
| Subcellular Location |
Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
|
| Tissue Specificity |
Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas. {ECO:0000269|PubMed:10984498, ECO:0000269|PubMed:11114196, ECO:0000269|PubMed:11171996}.
|