Gene Symbol | MYOZ1 |
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Entrez Gene | 58529 |
Alt Symbol | CS-2, FATZ, MYOZ |
Species | Human |
Gene Type | protein-coding |
Description | myozenin 1 |
Other Description | calsarcin-2|filamin-, actinin- and telethonin-binding protein|myozenin-1 |
Swissprots | Q9NP98 Q9H1I7 |
Accessions | AAG27296 EAW54506 Q9NP98 AA176752 AF240633 AAG24509 AJ278124 CAB92967 AK300683 BAG62366 AK308200 AL359210 CAB94568 AY013297 AAG38940 BC025753 AAH25753 DQ891549 ABM82475 DQ894737 ABM85663 NM_021245 NP_067068 |
Function | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
Subcellular Location | Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle. |
Tissue Specificity | Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas. {ECO:0000269|PubMed:10984498, ECO:0000269|PubMed:11114196, ECO:0000269|PubMed:11171996}. |
Myozenin 1 CRISPR/Cas9 KO Plasmid (h) - sc-410083 from Santa Cruz Biotechnology
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Myozenin 1 HDR Plasmid (h) - sc-410083-HDR from Santa Cruz Biotechnology
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Myozenin 1 Double Nickase Plasmid (h) - sc-410083-NIC from Santa Cruz Biotechnology
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Myozenin 1 Double Nickase Plasmid (h2) - sc-410083-NIC-2 from Santa Cruz Biotechnology
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Myozenin 1 CRISPR Activation Plasmid (h) - sc-410083-ACT from Santa Cruz Biotechnology
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Myozenin 1 CRISPR Activation Plasmid (h2) - sc-410083-ACT-2 from Santa Cruz Biotechnology
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Myozenin 1 Lentiviral Activation Particles (h) - sc-410083-LAC from Santa Cruz Biotechnology
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Myozenin 1 Lentiviral Activation Particles (h2) - sc-410083-LAC-2 from Santa Cruz Biotechnology
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Myozenin 1 siRNA (h) - sc-90433 from Santa Cruz Biotechnology
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Myozenin 1 shRNA Plasmid (h) - sc-90433-SH from Santa Cruz Biotechnology
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Myozenin 1 shRNA (h) Lentiviral Particles - sc-90433-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU072861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14878 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14878 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01672 from Sigma-Aldrich
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MYOZ1 siRNA (Human) - CRJ1749 from Cohesion Biosciences
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Myozenin 1 RNAi - H00058529-R01 from Novus Biologicals
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shRNA set against Human MYOZ1 (NM_021245.3) - SHH348464 from Creative biogene
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Human MYOZ1 siRNA - orb272250 from Biorbyt
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MYOZ1 shRNA Plasmid (Human) - CHJ1749 from Cohesion Biosciences
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MYOZ1 miRNA 3'UTR clone - MiUTR3H-07822 from Creative biogene
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