| Gene Symbol |
PSMB5
|
| Entrez Gene |
5693
|
| Alt Symbol |
LMPX, MB1, X
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) subunit, beta type, 5
|
| Other Description |
PSX large multifunctional protease X|macropain epsilon chain|multicatalytic endopeptidase complex epsilon chain|proteasome beta 5 subunit|proteasome catalytic subunit 3|proteasome chain 6|proteasome epsilon chain|proteasome subunit MB1|proteasome subunit X|proteasome subunit beta type-5|proteasome subunit, beta type, 5
|
| Swissprots |
Q86T01 Q9TNN9 B2R4N9 Q16242 P28074 B4DUM9 E9PAV2 Q6PEW2 Q7Z3B5 D3DS43
|
| Accessions |
CAA64838 EAW66193 EAW66194 EAW66195 P28074 AK225888 AK300714 BAG62391 AK311895 BAG34836 BC057840 AAH57840 BC107720 AAI07721 BT006777 AAP35423 BU539357 BU632351 BX248299 CAD62626 BX538001 CAD97956 CD048996 HQ448536 ADQ33015 S74378 AAB33092 XM_005267871 XP_005267928 NM_001130725 NP_001124197 NM_001144932 NP_001138404 NM_002797 NP_002788
|
| Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Top Pathways |
Proteasome
|
![Western Blot: PSMB5 Overexpression Lysate (Adult Normal) [NBL1-14880] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PSMB5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4732_PSMB5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14880-img0002.jpg)