| Gene Symbol |
MGME1
|
| Entrez Gene |
92667
|
| Alt Symbol |
C20orf72, DDK1, MTDPS11, bA504H3.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial genome maintenance exonuclease 1
|
| Other Description |
-
|
| Swissprots |
B2RDG5 Q96SW3 Q9BQP7 D3DW29
|
| Accessions |
EAX10260 EAX10261 EAX10262 Q9BQP7 AF306684 AF306685 AF306686 AK027503 BAB55160 AK309563 AK309995 AK310282 AK315532 BAG37912 BC016869 AAH16869 HQ447812 ADQ32296 XM_005260866 XP_005260923 XM_005260867 XP_005260924 XM_005260870 XP_005260927 XM_006723663 XP_006723726 XM_011529394 XP_011527696 XM_011529395 XP_011527697 NM_052865 NP_443097
|
| Function |
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP- Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.
|
| Subcellular Location |
Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.
|
