MGME1

Gene Symbol MGME1
Entrez Gene 92667
Alt Symbol C20orf72, DDK1, MTDPS11, bA504H3.4
Species Human
Gene Type protein-coding
Description mitochondrial genome maintenance exonuclease 1
Other Description -
Swissprots B2RDG5 Q96SW3 Q9BQP7 D3DW29
Accessions EAX10260 EAX10261 EAX10262 Q9BQP7 AF306684 AF306685 AF306686 AK027503 BAB55160 AK309563 AK309995 AK310282 AK315532 BAG37912 BC016869 AAH16869 HQ447812 ADQ32296 XM_005260866 XP_005260923 XM_005260867 XP_005260924 XM_005260870 XP_005260927 XM_006723663 XP_006723726 XM_011529394 XP_011527696 XM_011529395 XP_011527697 NM_052865 NP_443097
Function Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP- Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.
Subcellular Location Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.

C20orf72 CRISPR/Cas9 KO Plasmid (h) - sc-407857 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 HDR Plasmid (h) - sc-407857-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 Double Nickase Plasmid (h) - sc-407857-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 Double Nickase Plasmid (h2) - sc-407857-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 CRISPR Activation Plasmid (h) - sc-407857-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 CRISPR Activation Plasmid (h2) - sc-407857-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 Lentiviral Activation Particles (h) - sc-407857-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 Lentiviral Activation Particles (h2) - sc-407857-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C20orf72 siRNA (h) - sc-72743 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C20orf72 shRNA Plasmid (h) - sc-72743-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

C20orf72 shRNA (h) Lentiviral Particles - sc-72743-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU054831 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4752 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4752 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MGME1 siRNA (Human) - CRJ4154 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C20orf72 (NM_052865.2) - SHH251105 from Creative biogene

Category siRNA
Species Reactivities Human

Human MGME1 siRNA - orb274655 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MGME1 shRNA Plasmid (Human) - CHJ4154 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C20ORF72 miRNA 3'UTR clone - MiUTR1H-01333 from Creative biogene

Species Reactivities Human
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