CELF2
| Gene Symbol | CELF2 |
|---|---|
| Entrez Gene | 10659 |
| Alt Symbol | BRUNOL3, CUGBP2, ETR-3, ETR3, NAPOR |
| Species | Human |
| Gene Type | protein-coding |
| Description | CUGBP, Elav-like family member 2 |
| Other Description | CELF-2|CUG triplet repeat RNA-binding protein 2|CUG-BP- and ETR-3-like factor 2|CUG-BP2|CUGBP Elav-like family member 2|ELAV-type RNA-binding protein 3|RNA-binding protein BRUNOL-3|bruno-like protein 3|neuroblastoma apoptosis-related RNA-binding protein |
| Swissprots | Q9UL67 Q7KYU4 Q96RQ5 Q92950 Q96NW9 Q96RQ6 B7ZAN9 Q8N499 O95319 |
| Accessions | AAK72223 AAK72224 AAK92699 EAW86346 EAW86347 EAW86348 EAW86349 EAW86350 O95319 AA595891 AF036956 AAD02074 AF086447 AF090693 AAD13760 AF090694 AAD13761 AF432906 AAL27627 AK293164 BAG56708 AK295511 BAG58428 AK297313 BAG59778 AK297380 BAG59822 AK299548 BAG61493 AK299983 BAG61804 AK299992 BAG61812 AK302681 BAG63913 AK304216 BAG65088 AK310038 AK314087 BAG36783 AK316354 BAH14725 AW965523 BC036391 AAH36391 BC050635 BE275530 BI914655 BM699598 BP229421 BP362205 BQ213648 BU173199 CD556770 CN356737 CR936676 CR976278 DA310511 DA819821 DB478862 U69546 AAB09040 XM_005252354 XP_005252411 XM_005252357 XP_005252414 XM_005252358 XP_005252415 XM_006717369 XP_006717432 XM_006717370 XP_006717433 XM_006717371 XP_006717434 XM_006717373 XP_006717436 XM_006717374 XP_006717437 XM_006717375 XP_006717438 XM_011519294 XP_011517596 XM_011519295 XP_011517597 XM_011519296 XP_011517598 XM_011519297 XP_011517599 XM_011519298 XP_011517600 XM_011519299 XP_011517601 NM_001025076 NP_001020247 NM_001025077 NP_001020248 NM_001083591 NP_001077060 NM_006561 NP_006552 |
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre- mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostagl |
| Subcellular Location | Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. {ECO:0000250}. |
| Tissue Specificity | Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10524244, ECO:0000269|PubMed:10893231, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:11414768, ECO:0000269|PubMed:16862542}. |
CUG-BP2 CRISPR/Cas9 KO Plasmid (h) - sc-403267 from Santa Cruz Biotechnology
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CUG-BP2 HDR Plasmid (h) - sc-403267-HDR from Santa Cruz Biotechnology
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CUG-BP2 Double Nickase Plasmid (h) - sc-403267-NIC from Santa Cruz Biotechnology
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CUG-BP2 Double Nickase Plasmid (h2) - sc-403267-NIC-2 from Santa Cruz Biotechnology
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CUG-BP2 CRISPR Activation Plasmid (h) - sc-403267-ACT from Santa Cruz Biotechnology
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CUG-BP2 CRISPR Activation Plasmid (h2) - sc-403267-ACT-2 from Santa Cruz Biotechnology
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CUG-BP2 Lentiviral Activation Particles (h) - sc-403267-LAC from Santa Cruz Biotechnology
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CUG-BP2 Lentiviral Activation Particles (h2) - sc-403267-LAC-2 from Santa Cruz Biotechnology
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CUG-BP2 siRNA (h) - sc-44554 from Santa Cruz Biotechnology
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CUG-BP2 shRNA Plasmid (h) - sc-44554-SH from Santa Cruz Biotechnology
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CUG-BP2 shRNA (h) Lentiviral Particles - sc-44554-V from Santa Cruz Biotechnology
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CUGBP2 RNAi - H00010659-R01 from Novus Biologicals
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CUGBP2 RNAi - H00010659-R02 from Novus Biologicals
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CUGBP2 RNAi - H00010659-R03 from Novus Biologicals
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MISSION® esiRNA - EHU073251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5926 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5926 from Sigma-Aldrich
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CELF2 siRNA (Human) - CRH7267 from Cohesion Biosciences
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CELF2 - MBS8201507 from MyBioSource
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CUG-BP2 CRISPR/Cas9 KO Plasmid (h2) - sc-403267-KO-2 from Santa Cruz Biotechnology
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CUG-BP2 HDR Plasmid (h2) - sc-403267-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CELF2 (NM_006561.3) - SHH261485 from Creative biogene
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shRNA set against Human CUGBP2(NM_001083591.1) - SHG210945 from Creative biogene
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shRNA set against Human CUGBP2(NM_001025077.2) - SHG210949 from Creative biogene
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shRNA set against Human CUGBP2(NM_001025076.2) - SHG211381 from Creative biogene
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