HMGCS2

Gene Symbol	HMGCS2
Entrez Gene	3158
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Other Description	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)|HMG-CoA synthase|hydroxymethylglutaryl-CoA synthase, mitochondrial
Swissprots	D3Y5K6 Q6IBF4 B7Z8R3 P54868 Q5SZU2
Accessions	AAB72036 EAW56709 EAW56710 P54868 AI215948 AK301594 BAH13520 AK302276 BAH13664 AK303777 BAH14049 AK313590 BC044217 AAH44217 BF964973 BP420631 BX104280 CR456850 CAG33131 GU433940 ADD21696 U12788 AAA92673 U12789 AAA92674 X83618 CAA58593 XM_011541313 XP_011539615 NM_001166107 NP_001159579 NM_005518 NP_005509
Function	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Subcellular Location	Mitochondrion.
Tissue Specificity	Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. The relative expression of isoform 3 (at mRNA level) is highest in heart (70%) and skeletal muscle (60%). {ECO:0000269|PubMed:16940161, ECO:0000269|PubMed:21952825, ECO:0000269|PubMed:7893153}.
Top Pathways	Terpenoid backbone biosynthesis, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HMGCS2 293T Cell Transient Overexpression Lysate(Denatured) - H00003158-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HMGCS2 overexpression lysate - LY417253 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HMGCS2 overexpression lysate - LY431416 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HMGCS2 Overexpression Lysate (Denatured) - H00003158-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

HMGCS2 Overexpression Lysate (Native) - NBP2-10151 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HMGCS2 Overexpression Lysate (Native) - NBP2-07739 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HMGCS2 Overexpression Lysate (Denatured) - H00003158-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human HMGCS2 Knockdown Stable Cell Line - CSC-DC007124 from Creative biogene Category Cell Line Species Human

Search more