HMGCS2

Gene Symbol HMGCS2
Entrez Gene 3158
Alt Symbol -
Species Human
Gene Type protein-coding
Description 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Other Description 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)|HMG-CoA synthase|hydroxymethylglutaryl-CoA synthase, mitochondrial
Swissprots D3Y5K6 Q6IBF4 B7Z8R3 P54868 Q5SZU2
Accessions AAB72036 EAW56709 EAW56710 P54868 AI215948 AK301594 BAH13520 AK302276 BAH13664 AK303777 BAH14049 AK313590 BC044217 AAH44217 BF964973 BP420631 BX104280 CR456850 CAG33131 GU433940 ADD21696 U12788 AAA92673 U12789 AAA92674 X83618 CAA58593 XM_011541313 XP_011539615 NM_001166107 NP_001159579 NM_005518 NP_005509
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Subcellular Location Mitochondrion.
Tissue Specificity Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. The relative expression of isoform 3 (at mRNA level) is highest in heart (70%) and skeletal muscle (60%). {ECO:0000269|PubMed:16940161, ECO:0000269|PubMed:21952825, ECO:0000269|PubMed:7893153}.
Top Pathways Terpenoid backbone biosynthesis, PPAR signaling pathway, Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism

mHMGCS CRISPR/Cas9 KO Plasmid (h) - sc-403941 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS HDR Plasmid (h) - sc-403941-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS Double Nickase Plasmid (h) - sc-403941-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS Double Nickase Plasmid (h2) - sc-403941-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS CRISPR Activation Plasmid (h) - sc-403941-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS CRISPR Activation Plasmid (h2) - sc-403941-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS Lentiviral Activation Particles (h) - sc-403941-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS Lentiviral Activation Particles (h2) - sc-403941-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

mHMGCS siRNA (h) - sc-44503 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mHMGCS shRNA Plasmid (h) - sc-44503-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

mHMGCS shRNA (h) Lentiviral Particles - sc-44503-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU144921 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10168 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10168 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12134 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12134

HMGCS2 siRNA (Human) - CRH2155 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HMGCS2 - MBS8207672 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HMGCS2 (NM_005518.3) - SHH313397 from Creative biogene

Category siRNA
Species Reactivities Human

Human HMGCS2 siRNA - orb262657 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HMGCS2 shRNA Plasmid (Human) - CHH2155 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HMGCS2 miRNA 3'UTR clone - MiUTR3H-03203 from Creative biogene

Species Reactivities Human

HMGCS2 miRNA 3'UTR clone - MiUTR3H-03204 from Creative biogene

Species Reactivities Human
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