| Gene Symbol |
NEDD4L
|
| Entrez Gene |
23327
|
| Alt Symbol |
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase NEDD4-like|ubiquitin-protein ligase Rsp5
|
| Swissprots |
Q7Z5F1 Q9BW58 Q96PU5 Q9NT88 Q7Z5N3 Q3LSM7 Q8WUU9 Q9H2W4 O43165 Q7Z5F2 Q8N5A7
|
| Accessions |
CAS01775 EAW63064 EAW63065 EAW63066 EAW63067 EAW63068 EAW63069 EAW63070 EAW63071 EAW63072 EAW63073 EAW63074 EAW63075 Q96PU5 AB007899 BAA23711 AB071179 BAB69424 AF070601 AF210730 AAG43524 AF385931 AAM46208 AK091189 AK130420 AK294963 BAH11935 AK300444 BAH13286 AL137469 CAB70754 AY112983 AAM76728 AY112984 AAM76729 AY112985 AAM76730 AY243313 AAP97872 AY243314 AY243315 AY243316 AAP97873 AY243317 AY243318 AY243319 AY243321 AY243322 AY256662 AY312514 AAP75706 AY751751 AAU95503 BC000621 AAH00621 BC019345 AAH19345 BC032597 AAH32597 BP260852 BQ215431 DA248109 DA759940 DA819220 DB317092 DB473368 DC363885 DC381911 DQ181796 ABA10330 DQ890913 ABM81839 DQ893350 ABM84276 XM_005266658 XP_005266715 XM_005266660 XP_005266717 XM_005266663 XP_005266720 XM_006722421 XP_006722484 XM_006722424 XP_006722487 XM_006722425 XP_006722488 XM_006722426 XP_006722489 XM_006722428 XP_006722491 XM_006722430 XP_006722493 XM_011525887 XP_011524189 NM_001144964 NP_001138436 NM_001144965 NP_001138437 NM_001144966 NP_001138438 NM_001144967 NP_001138439 NM_001144968 NP_001138440 NM_001144969 NP_001138441 NM_001144970 NP_001138442 NM_001144971 NP_001138443 NM_001243960 NP_001230889 NM_015277 NP_056092
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. {ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:18819914}. Note=May be recruited to exosomes by NDFIP1.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. {ECO:0000269|PubMed:14615060, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:19664597}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Endocytosis, Aldosterone-regulated sodium reabsorption
|