| Gene Symbol | FKBP6 |
|---|---|
| Entrez Gene | 8468 |
| Alt Symbol | FKBP36 |
| Species | Human |
| Gene Type | protein-coding |
| Description | FK506 binding protein 6, 36kDa |
| Other Description | 36 kDa FKBP|PPIase FKBP6|immunophilin FKBP36|inactive PPIase FKBP6|inactive peptidyl-prolyl cis-trans isomerase FKBP6|peptidyl-prolyl cis-trans isomerase FKBP6|rotamase |
| Swissprots | Q9UDS0 O75344 B4DXT7 Q7Z4T4 G3V0I2 |
| Accessions | CBH19283 EAW69684 EAW69685 EAW69686 O75344 AA909474 AF038847 AAC64249 AF447060 AAP97324 AK302121 BAG63499 AK310255 BC036817 AAH36817 BI461016 DB033483 DB450796 DB525126 EU176233 ABW03684 EU176537 ABW03338 GQ129339 ACT64473 GQ129340 ACT64474 XM_005250643 XP_005250700 XM_006716152 XP_006716215 XM_006716153 XP_006716216 XM_011516644 XP_011514946 NM_001135211 NP_001128683 NM_001281304 NP_001268233 NM_003602 NP_003593 |
| Function | Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. |